Evidence map›Paper›PMID 41736071›Full record

ArticleJournal of biomedical science2026

TGF-β signaling mediates crosstalk between CD8

Ye Chen, Jun Long Dang, Qi Long, Nianke Zang, Ling Liu, Yang Lu, Wei Zhao, Rong Zhen Liang, Yi Yang, Jun Zhao and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ye Chen *Division of Rheumatology and Immunology, Department of Internal Medicine, Shanghai Songjiang Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China.
Jun Long Dang *Division of Rheumatology and Immunology, Department of Internal Medicine, Shanghai Songjiang Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China.
Qi Long *Division of Rheumatology and Immunology, Department of Internal Medicine, Shanghai Songjiang Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China.
Nianke Zang *The First Dongguan Affiliated Hospital, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, School of Medical Technology, State Key Laboratory of Pathogenesis, Guangdong Medical University, Dongguan, 523710, China.
Ling LiuDivision of Rheumatology and Immunology, Department of Internal Medicine, Shanghai Songjiang Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China.
Yang LuDivision of Rheumatology and Immunology, Department of Internal Medicine, Shanghai Songjiang Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China.
Wei ZhaoDivision of Rheumatology and Immunology, Department of Internal Medicine, Shanghai Songjiang Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China.
Rong Zhen LiangDivision of Rheumatology and Immunology, Department of Internal Medicine, Shanghai Songjiang Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China.
Yi YangDepartment of Endocrinology and Metabolic Diseases, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, Guangdong, China.
Jun ZhaoDivision of Rheumatology and Immunology, Department of Internal Medicine, Shanghai Songjiang Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China.
Jing Rong ChenDivision of Rheumatology and Immunology, Department of Internal Medicine, Shanghai Songjiang Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China.
Yi Ding XiongDivision of Rheumatology and Immunology, Department of Internal Medicine, Shanghai Songjiang Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China.
Julie WangDivision of Rheumatology and Immunology, Department of Internal Medicine, Shanghai Songjiang Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China.
Yun Feng PanDivision of Rheumatology, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510000, China.
Nancy OlsenDivision of Rheumatology, Penn State College of Medicine and Milton S. Hershey Medical Center, Hershey, PA, 17033, USA.
Song Guo ZhengDivision of Rheumatology and Immunology, Department of Internal Medicine, Shanghai Songjiang Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China. Song.Zheng@shsmu.edu.cn.

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2022A1515111173National Natural Science Foundation of China 81871224National Natural Science Foundation of China 82001727National Natural Science Foundation of China 82371817Shanghai Songjiang District Research Foundation 2024SJKJGG059Shanghai Songjiang District Research Foundation 2024SJKJGG076
6 · The paper itself

Abstract

backgroundAutoimmune inflammation results from dysregulated immune responses, with dysfunction of regulatory T cells (Tregs) being a key contributor due to their critical role in maintaining immune tolerance. The stability and function of Tregs are strongly influenced by the inflammatory microenvironment, yet the regulatory interactions between CD8

methodsWe investigated the role of CD8

resultsCD8

conclusionsThis study identifies a previously unrecognized role of CD8

Indexed as

Autoimmune DiseasesCD8-Positive T-LymphocytesInflammationSignal TransductionT-Lymphocytes, RegulatoryTransforming Growth Factor betaAnimalsAntigens, CDApyraseColitisFemaleMiceMice, Inbred C57BLAntigens, CDApyraseCD39 antigenTransforming Growth Factor betaAutoimmune inflammationCD8+ T cellsInduced Treg cellsIRF4ROSTGF-β

Identifiers

PMID41736071
PMCPMC12933926

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.