Evidence map›Paper›PMID 41736062›Full record

ArticleBMC medicine2026

Health experiences and outcomes of autistic and non-autistic adults with hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorder.

Catherine J Crompton, Themis N Efthimiou, Dervil M Dockrell, Kathryn M Berg

Abstract read
In one paragraph

Article in BMC medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Catherine J CromptonUsher Institute, University of Edinburgh, Edinburgh, UK. catherine.crompton@ed.ac.uk.ORCID 0000-0001-5280-1596
Themis N EfthimiouCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-8458-5493
Dervil M DockrellInstitute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID 0000-0003-4656-6205
Kathryn M BergInstitute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-5972-4009

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious research has indicated an association between hypermobility and autism. This study examined whether being autistic affects diagnosis, symptoms, and health experiences of people with hypermobility, including hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobility spectrum disorders (HSD). We compare three groups: autistic adults, non-autistic adults, and adults who are not autistic but have a high level of autistic traits. Additionally, we examined which health and social factors predicted self-reported physical and mental health outcomes for autistic and non-autistic people with hEDS/HSD.

methodA total of 1754 participants completed an online questionnaire about their diagnostic experience, hypermobile symptoms, co-occurring health conditions, self-rated physical and mental health, engagement with health services, and employment and benefits status. Around 25% of respondents were autistic; a further 25% had high levels of autistic traits.

resultsAutistic participants had more symptoms of hEDS/HSD and were more likely to have co-occurring physical and mental health conditions, compared with non-autistic and high autistic trait respondents. Autistic and high autistic trait participants self-reported poorer physical and mental health compared with non-autistic participants. Autistic participants' mental health was impacted by limitations to everyday activities, whereas non-autistic participants were more impacted by difficulties with self-care.

conclusionsAutistic and non-autistic people may experience hEDS/HSD differently, which may impact the type of supports that are most beneficial to them.

Indexed as

Autistic DisorderEhlers-Danlos SyndromeJoint InstabilityAdolescentAdultFemaleHumansMaleMiddle AgedSurveys and QuestionnairesYoung AdultAutismHypermobile Ehlers-Danlos syndromeHypermobilityHypermobility spectrum disorder

Identifiers

PMID41736062
PMCPMC13040810

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.