ArticleItalian journal of pediatrics2026
Impact of cerebral oxygenation-guided resuscitation during immediate postnatal transition on brain injury and brain growth detected by MRI in very preterm neonates: a secondary outcome analysis of the multicenter randomized phase 3 clinical COSGOD III trial.
Article in Italian journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prospective, randomized-controlled multicenter COSGOD III trial was designed to investigate whether interventions guided by cerebral oxygen saturation (crSO2) measured with near-infrared spectroscopy (NIRS group) during the immediate postnatal transition increase survival without cerebral injury of very preterm infants compared with standard care alone (control group). The aim of this secondary outcome study was to compare brain injury and brain growth between the two groups, as assessed by magnetic resonance imaging (MRI) at near-term age.
methodsPatients from five centers participating in the COSGOD III trial, which performed near-term MRI, were evaluated for the presence of brain injury (intraventricular hemorrhage, cerebellar hemorrhage, white matter injury) and brain growth (transcerebellar/biparietal diameter, interhemispheric distance).
resultsThis study included 172 infants (86 per group) with a median gestational age of 28.4 weeks and a median birth weight of 1045 grams. The incidence of brain injury did not differ between the groups. Infants in the NIRS group exhibited a significantly larger median biparietal diameter (median [IQR] 78.6 [76.3–82.1] mm) compared to the control group (76.7 [74.7–80.0] mm). A trend toward a lower rate of abnormal biparietal diameter was observed in the NIRS group.
conclusionsMonitoring of crSO2 with dedicated treatment guidelines during the immediate postnatal transition had no effect on the incidence of brain injury assessed by MRI. The significantly larger biparietal diameter in the NIRS group may be indicative of enhanced brain development. The relationship between this structural advance in the NIRS group and long-term functional outcomes requires further investigation.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.