ArticleClinical proteomics2026
Comparative proteomic analysis of gingival crevicular fluid and periodontal tissue: revealing clinical potential.
Article in Clinical proteomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundPeriodontitis is a chronic inflammatory disease characterized by tissue destruction and immune dysregulation. While gingival crevicular fluid (GCF) serves as a non-invasive biomarker source, its molecular distinctions from periodontal tissue remain underexplored. This study conducted a comparative proteomic analysis of GCF and tissue samples from patients with Stage III-IV periodontitis, integrating differential expression, weighted gene co-expression network analysis, and protein-protein interaction networks to delineate compartment-specific molecular profiles and clarify their respective biological roles in periodontal pathophysiology.
methodsProteomic data were acquired from GCF and periodontal tissue using label-free LC-MS analysis. Differentially expressed proteins (DEPs) were identified using independent samples t-test (p < 0.05, |fold-change| > 2). WGCNA was performed to construct co-expression modules and identify functionally related protein clusters, followed by GO enrichment and protein-protein interaction (PPI) analyses using STRING and Cytoscape. Hub proteins were determined through CytoHubba according to centrality measures. Comparative analyses were conducted between tissue and GCF to define inflammation- and repair-related modules and to assess potential molecular interconnections between the two sample types.
resultsA total of 4,
conclusionsThis comparative proteomic analysis demonstrates that periodontal tissue and GCF represent functionally distinct but complementary biological environments in periodontitis. Periodontal tissue exhibits enhanced structural and metabolic processes, whereas GCF predominantly reflects neutrophil-mediated immune responses. These molecular distinctions provide a basis for developing clinical, compartment-specific biomarker candidates that warrant analytical validation, thereby supporting precision-medicine-relevant diagnostic strategies in periodontal research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.