ArticleBMC microbiology2026
Emergence of bla
Article in BMC microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Epidemiology, resistance profiles, and molecular characteristics of pediatric salmonella isolates: prevalence of a clonalFrontiers in cellular and infection microbiology · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to retrospectively analyze Salmonella Thompson isolates collected at our research center and to investigate the genetic characteristics of Salmonella Thompson by integrating isolates from the present study with publicly available global genomic data, with a particular focus on the ST26 clone.
methodsThis retrospective genomic epidemiological study investigated Salmonella Thompson isolates collected from a tertiary hospital in northern China between 2018 and 2023. We employed antimicrobial susceptibility testing, short-read and long-read whole-genome sequencing, phylogenomic analysis, and plasmid structure characterization. All Salmonella Thompson genomes from the NCBI GenBank database were included in comparative genomic analysis.
resultsAll Salmonella Thompson strains in this study belonged to ST26. Strain WFS122 carried blaNDM−5, which was located on a common IncX3-type plasmid found in NDM-positive Escherichia coli and Klebsiella pneumoniae strains (100% homology). Analysis of the public database revealed that ST26 is the globally predominant lineage of Salmonella Thompson, accounting for 89.57% of strains and harboring the overwhelming majority of resistance genes and Class 1 integrons. We further identified Clade D4 as a high-risk evolutionary branch with elevated resistance rates. Within this study, 96.15% of Clade D4 strains harbored Class 1 integrons, which were pivotal in resistance gene carriage, primarily encoding the aminoglycoside resistance gene aadA and the trimethoprim resistance gene dfrA.
conclusionWe hypothesize that ST26 Salmonella Thompson exhibits global expansion, with the high-risk clone Clade D4 showing a strong association with Class 1 integrons and resistance genes. This high-risk clone has demonstrated potential for transmission in China, the United States, and the United Kingdom, necessitating expanded research scope and scale. Additionally, this study represents the identification of NDM-5-carrying ST26 Salmonella Thompson. The emergence of carbapenem-resistant Salmonella Thompson poses a significant challenge for clinical management of Salmonella infections caused by this strain.
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