ArticleAngewandte Chemie (International ed. in English)2026
More Than a Buffer in Biochemistry: Tris as an Architect and Gatekeeper of Metal-Oxo Assembly.
Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- More Than a Buffer in Biochemistry: Tris as an Architect and Gatekeeper of Metal-Oxo Assembly.Angewandte Chemie (International ed. in English) · 2026Article
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2 authors.
Funding
Abstract
Polyoxometalates (POMs, molecular metal-oxo clusters) are typically studied and applied in aqueous media, where routine buffers determine which clusters form, persist, or react. Tris(hydroxymethyl)aminomethane (Tris) is a ubiquitous buffer near physiological pH and has produced outcomes that pH control alone could not explain, prompting a simple question with large consequences: What does Tris actually do to POMs? Quantification across several POM families shows that this loose buffering correlates with longer lifetimes of intact anions, the formation of Tris-specific adducts, and tunable stability through ionic-strength adjustment. We describe three molecular roles of Tris. First, Tris acts as an alkoxy donor that embeds μ-O─CH
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