Evidence map›Paper›PMID 41735680›Full record

ArticleEye (London, England)2026

Feasibility and reproducibility of handheld and table-mounted optical coherence tomography in children with craniosynostosis.

Sohaib R Rufai, Dermot Roche, Riddhi Shenoy, Oliver R Marmoy, Vasiliki Panteli, Dorothy A Thomson, Robert H Henderson, Irene Gottlob, Mervyn G Thomas, Catey Bunce and 3 more

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In one paragraph

Article in Eye (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sohaib R RufaiClinical and Academic Department of Ophthalmology, Great Ormond Street Hospital for Children NHS Foundation Trust and UCL Great Ormond Street Institute of Child Health, London, UK.ORCID http://orcid.org/0000-0001-8134-6393
Dermot RocheClinical and Academic Department of Ophthalmology, Great Ormond Street Hospital for Children NHS Foundation Trust and UCL Great Ormond Street Institute of Child Health, London, UK.
Riddhi ShenoyThe University of Leicester Ulverscroft Eye Unit, Leicester Royal Infirmary, Leicester, UK.
Oliver R MarmoyClinical and Academic Department of Ophthalmology, Great Ormond Street Hospital for Children NHS Foundation Trust and UCL Great Ormond Street Institute of Child Health, London, UK.
Vasiliki PanteliClinical and Academic Department of Ophthalmology, Great Ormond Street Hospital for Children NHS Foundation Trust and UCL Great Ormond Street Institute of Child Health, London, UK.
Dorothy A ThomsonClinical and Academic Department of Ophthalmology, Great Ormond Street Hospital for Children NHS Foundation Trust and UCL Great Ormond Street Institute of Child Health, London, UK.ORCID http://orcid.org/0000-0001-5491-3911
Robert H HendersonClinical and Academic Department of Ophthalmology, Great Ormond Street Hospital for Children NHS Foundation Trust and UCL Great Ormond Street Institute of Child Health, London, UK.ORCID http://orcid.org/0000-0002-5250-6404
Irene GottlobThe University of Leicester Ulverscroft Eye Unit, Leicester Royal Infirmary, Leicester, UK.
Mervyn G ThomasThe University of Leicester Ulverscroft Eye Unit, Leicester Royal Infirmary, Leicester, UK.
Catey BunceEpidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.ORCID http://orcid.org/0000-0002-0935-3713
Noor Ul Owase JeelaniCraniofacial Unit, Great Ormond Street Hospital for Children NHS Foundation Trust and UCL Great Ormond Street Institute of Child Health, London, UK.
Richard BowmanClinical and Academic Department of Ophthalmology, Great Ormond Street Hospital for Children NHS Foundation Trust and UCL Great Ormond Street Institute of Child Health, London, UK.
Frank A ProudlockThe University of Leicester Ulverscroft Eye Unit, Leicester Royal Infirmary, Leicester, UK. fap1@leicester.ac.uk.

Funding

DH | National Institute for Health Research (NIHR) CL-2022-11-001DH | National Institute for Health Research (NIHR) NIHR300155RCUK | Medical Research Council (MRC) MR/N004566/1
6 · The paper itself

Abstract

backgroundOptical coherence tomography (OCT) can be a valuable tool for non-invasively monitoring the optic nerve status in children with craniosynostosis. However, it is currently unknown whether optic nerve parameters derived from handheld OCT are comparable to those derived from table-mounted OCT, which is more widely used. This study aims to assess the feasibility and reproducibility of handheld and table-mounted OCT in craniosynostosis.

methodsThis was a cross-sectional study conducted at Great Ormond Street Hospital (GOSH), London. Twenty children aged 4-18 years with a clinical/genetic diagnosis of craniosynostosis were included. Bilateral optic nerve head OCT imaging was performed using the Spectralis (Heidelberg Engineering), followed by the handheld Envisu C2300 (Leica Microsystems). Primary outcome measures were quantitative cup, disc, rim and peripapillary parameters. Intraclass correlation coefficients (ICC) and coefficient of variation (CoV) were calculated for each quantitative OCT parameter.

results20 children (100%) were successfully recruited. Median age at the time of OCT examination was 6 years (range: 4-16; IQR: 5-8). Ten participants (50%) were female. Seven participants (35%) had syndromic craniosynostosis and 13 participants (65%) had non-syndromic craniosynostosis. Bilateral imaging success was 100% for both machines. ICCs were good-to-excellent for all parameters, ranging from 0.81 to 1.00. The coefficient of variation was low for all parameters.

conclusionsOCT imaging of the optic nerve is feasible in school-aged children with craniosynostosis and comparable between the Spectralis and handheld Envisu OCT. This could allow comparison and pooling of data between the two machines, greatly enhancing patient care and future research.

Indexed as

CraniosynostosesOptic DiskOptic Nerve DiseasesTomography, Optical CoherenceAdolescentChildChild, PreschoolCross-Sectional StudiesFeasibility StudiesFemaleHumansMaleReproducibility of Results

Identifiers

PMID41735680
PMCPMC13161219

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.