Evidence map›Paper›PMID 41735650›Full record

SynthesisNeurosurgical review2026

Cushing's disease and negative MRI: a single-center series, systematic literature review, and meta-analysis.

Francesca Ghidoni, Alba Madoglio, Sabrina Chiloiro, Lodovico Terzi di Bergamo, Marika Vezzoli, Simona Serioli, Giada Cosentino, Giorgio Saraceno, Isabella Lupi, Claudio Urbani and 18 more

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neurosurgical review, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Francesca Ghidoni *Department of Translational Medicine and for Romagna, University of Ferrara, Ferrara, Italy.
Alba Madoglio *Department of Translational Medicine and for Romagna, University of Ferrara, Ferrara, Italy.
Sabrina ChiloiroPituitary Unit, Department of Endocrinology and Diabetes, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.
Lodovico Terzi di BergamoInstitute of Oncology Research, Bellinzona, Switzerland.
Marika VezzoliBiostatistics, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Simona SerioliDepartment of Neurosurgery, Papa Giovanni XXIII, Bergamo, Italy.
Giada CosentinoDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Giorgio SaracenoNeurosurgery, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
Isabella LupiDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Claudio UrbaniDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Massimo LiciniDepartment of Clinical and Experimental Sciences, ASST Spedali Civili of Brescia, SSD Endocrinologia, University of Brescia, Brescia, Italy.
Renato CandrinaEndocrinology, Diabetology and Metabolic Diseases, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy.
Antonella GiampietroPituitary Unit, Department of Endocrinology and Diabetes, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.
Ilenia PirolaDepartment of Clinical and Experimental Sciences, ASST Spedali Civili of Brescia, SSD Endocrinologia, University of Brescia, Brescia, Italy.
Carlo CappelliDepartment of Clinical and Experimental Sciences, ASST Spedali Civili of Brescia, SSD Endocrinologia, University of Brescia, Brescia, Italy.
Davide MattavelliUnit of Otorhinolaryngology-Head and Neck Surgery, Department of Surgical Specialties, Radiological Sciences and Public Health, ASST Spedali Civili of Brescia, University of Brescia, Brescia, Italy.
Vittorio RampinelliUnit of Otorhinolaryngology-Head and Neck Surgery, Department of Surgical Specialties, Radiological Sciences and Public Health, ASST Spedali Civili of Brescia, University of Brescia, Brescia, Italy.
Marco FerrariOtorhinolaryngology-Head and Neck Surgery, Department of Neuroscience, University of Padua, Padua, Italy.
Fausto BogazziDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Mirco CosottiniNeuroradiology, Department of Translational Research On New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Roberto GasparottiNeuroradiology, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
Luca ManettiDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Antonio BianchiPituitary Unit, Department of Endocrinology and Diabetes, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.
Piero NicolaiOtorhinolaryngology-Head and Neck Surgery, Department of Neuroscience, University of Padua, Padua, Italy.
Cesare PiazzaUnit of Otorhinolaryngology-Head and Neck Surgery, Department of Surgical Specialties, Radiological Sciences and Public Health, ASST Spedali Civili of Brescia, University of Brescia, Brescia, Italy.
Marco Maria FontanellaNeurosurgery, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
Pietro Luigi Poliani *Pathology Unit, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Francesco Doglietto *Neurosurgery, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy. francesco.doglietto@unicatt.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cushing's Disease (CD) poses diagnostic and therapeutic challenges, particularly when pituitary MRI is negative for a neuroendocrine tumor (PitNET). This study systematically analyzes literature data on the surgical outcomes of patients with MRI-negative CD and presents a novel single-center series. A systematic review and meta-analysis of PubMed, Scopus, and Cochrane databases (2000-2024) were performed. A retrospective analysis of patients with MRI-negative CD who underwent endoscopic pituitary exploration between 2014 and 2021 at the University of Brescia was conducted. A meta-analysis of 35 studies revealed significant heterogeneity across studies (I

Indexed as

Magnetic Resonance ImagingPituitary ACTH HypersecretionHumansNeuroendocrine TumorsPituitary GlandPituitary NeoplasmsRetrospective StudiesACTH hyperplasiaCushing's diseaseHypercortisolismMRI negativePitNETPituitary exploration

Identifiers

PMID41735650
PMCPMC12932314

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.