Evidence map›Paper›PMID 41735568›Full record

ArticleThe Journal of antibiotics2026

Indigomycin, a new pyridinetrione from Streptomyces albus J1074 harboring the indigoidine biosynthetic gene cluster.

Jinfen Yuan, Tengfei Zhao, Zengguang Zhang, Chunshuai Huang

Abstract read
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Article in The Journal of antibiotics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jinfen YuanSchool of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, Yantai University, Yantai, China.
Tengfei ZhaoShandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, China.
Zengguang ZhangShandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, China.
Chunshuai HuangSchool of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, Yantai University, Yantai, China. huangchunshuai@simm.ac.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heterologous expression of the indigoidine biosynthetic gene cluster from Streptomyces laurentii ATCC 31255 in Streptomyces albus J1074 resulted in the production of the known blue pigment indigoidine, along with a structurally novel pyridinetrione derivative designated indigomycin (1). The structure of indigomycin was determined through comprehensive 1D and 2D NMR spectroscopy and X-ray crystallographic analysis. Antimicrobial evaluation revealed that indigomycin (1) exhibits modest activity against methicillin-resistant Staphylococcus aureus ATCC 43300, with a minimum inhibitory concentration (MIC) of 32 μg mL

Indexed as

Anti-Bacterial AgentsPyransStreptomycesCrystallography, X-RayMagnetic Resonance SpectroscopyMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMultigene FamilyPiperidonesAnti-Bacterial AgentsindigoidinePiperidonesPyrans

Identifiers

PMID41735568

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.