ArticleNature2026
Dynamic antigen expression and cytotoxic T cell resistance in HIV reservoir clones.
Abstract read
In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- PKC inhibitors reveal PKC isoforms involved in HIV latency reversal and immunomodulation.Journal of virology · 2026Article
- Antigen Stimulation Reactivates HIV-1 Proviruses Despite Integration in Repressive Chromatin.bioRxiv : the preprint server for biology · 2026Article
- What's Hot in HIV in 2025-A Basic and Translational Science Review From IDWeek 2025.The Journal of infectious diseases · 2026Review
- HIV-1 infection does not confer intrinsic resistance to cell death induced by cytotoxic T lymphocytes.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
- Update of
Authors and funding
37 authors.
Isabella A T M Ferreira *Infectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Alberto Herrera *Infectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.ORCID http://orcid.org/0000-0003-4189-9051
Tan Thinh HuynhInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.ORCID http://orcid.org/0009-0009-0286-3946
Emily StoneInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Noemi L LindenInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.ORCID http://orcid.org/0000-0001-5035-6716
Cristian OviesInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Yanqin RenInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Cintia BittarLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
Virender K PalLaboratory of Retrovirology, The Rockefeller University, New York, NY, USA.
Ethan NaingInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Parul SinhaInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.ORCID http://orcid.org/0009-0002-2372-1487
Ali DaneshInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Eva StevensonInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Shane VedovaInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Fitty LiuInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Louise LeyreInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Skylar SheaInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Elina WellsInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Itzayana G MillerInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.ORCID http://orcid.org/0000-0001-9199-8985
Marie CanisLaboratory of Retrovirology, The Rockefeller University, New York, NY, USA.
Ana Rafaela TeixeiraLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0003-1906-0102
Susan MoirLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.
Tae-Wook ChunLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-5153-7340
Colin KovacsMaple Leaf Medical Clinic and Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Madeleine S GastonguayInstitute for Computational Medicine and the Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-5700-8543
Alison L HillInstitute for Computational Medicine and the Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-6583-3623
Shy GenelCenter for Computational Astrophysics, Flatiron Institute, New York, NY, USA.
Paul ZumboApplied Bioinformatics Core, Weill Cornell Medicine, New York, NY, USA.
Doron BetelApplied Bioinformatics Core, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-8006-7752
Elias K HalvasDivision of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Guinevere Q LeeInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.ORCID http://orcid.org/0000-0002-9412-886X
Rachel ScheckInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.ORCID http://orcid.org/0009-0004-8354-9943
Marina CaskeyLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0003-1727-8693
Paul D BieniaszLaboratory of Retrovirology, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0002-2368-3719
Nathan L BoardInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA.ORCID http://orcid.org/0000-0002-5208-9970
Michel C NussenzweigLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.ORCID http://orcid.org/0000-0003-0592-8564
R Brad JonesInfectious Diseases Division, Department of Medicine, Weill Cornell Medical College, New York, NY, USA. rbjones@med.cornell.edu.ORCID http://orcid.org/0000-0003-4470-1231
Funding
WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6MREACH: Research Enterprise to Advance a Cure for HIVUM1AI164565 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Marina Caskey, R. Brad Jones · 2021 to 2026
$32.9MERASE HIV: Enterprise for Research and Advancements to Stop and Eradicate HIVUM1AI164562 · NIAID · EMORY UNIVERSITY · PI Deanna A Kulpa, Mirko Paiardini · 2021 to 2026
$30.0MHigh-Definition Characterization of the Persistence and Perturbation of the HIV Reservoir: Project 3P01AI169768 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Athe M. Tsibris · 2022 to 2026
$10.1MImmunologic control of HIV-1 through combination bNAbs and biologics.U01AI145921 · NIAID · ROCKEFELLER UNIVERSITY · PI CASKEY, MARINA · 2019 to 2024
$8.5MWeill Cornell/Rockefeller/Sloan Kettering MST ProgramT32GM152349 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI KATHARINE C HSU · 2024 to 2026
$6.6MINSPIRE: Innovative Strategies for Personalized Immunotherapies and Reservoir EradicationUM1AI191237 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Marina Caskey, R. Brad Jones · 2025 to 2026
$5.9MImpact of IL-15 immunotherapy on tissue-specific CD8 T cells to reduce the CNS HIV reservoir seeding and persistenceR01MH130197 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI Lishomwa C Ndhlovu, Afamefuna Okoye · 2022 to 2026
$5.1MTargeting HIV-specific T cell differentiation programs to enhance post-treatment control of HIVR01AI170239 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Rachel Lena Rutishauser · 2022 to 2026
$4.0MHIV-1 dynamics and evolution during trispecific broadly neutralizing antibody therapyR01AI157854 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI KURITZKES, DANIEL R., TSIBRIS, ATHE M. · 2021 to 2025
$4.0MTargeted delivery of cytopathicity enhancing agents, and co-ordination with shock and kill, to reduce HIV reservoirsR01AI147845 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI IRVINE, DARRELL J, JONES, R. BRAD · 2019 to 2023
$4.0MUnderstanding Immune Evasion by HIV-1 RepliclonesR01AI165031 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HALVAS, ELIAS K. · 2021 to 2025
$3.6MNIAID NIH HHS F31 AI191953NIAID NIH HHS K99 AI191911NIAID NIH HHS P01 AI169768NIAID NIH HHS R01 AI147845NIAID NIH HHS R01 AI150412NIAID NIH HHS R01 AI157854NIAID NIH HHS R01 AI165031NIAID NIH HHS R01 AI167691NIAID NIH HHS R01 AI170239NIAID NIH HHS R01 AI170245NIAID NIH HHS R01 AI176601NIAID NIH HHS R01 AI176943NIAID NIH HHS R21 AI170246NIAID NIH HHS R21 AI172554NIAID NIH HHS R37 AI181626NIAID NIH HHS U01 AI145921NIAID NIH HHS UM1 AI164562NIAID NIH HHS UM1 AI164565NIAID NIH HHS UM1 AI191237NIGMS NIH HHS T32 GM152349NIH HHS 75N91019D00024NIMH NIH HHS R01 MH130197
Abstract
Clonally expanded CD4
Indexed as
Disease ReservoirsHIV-1HIV InfectionsT-Lymphocytes, CytotoxicVirus LatencyCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell ProliferationClone CellsCoculture TechniquesHumansOxidative StressT-Lymphocytes, Regulatory
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What OpenQuestion holds
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.