Evidence map›Paper›PMID 41735465›Full record

ArticleScientific reports2026

Antimicrobial effects of novel Hermetia illucens peptides.

Emine Derin, Laurence Van Moll, Milan Wouters, Linda De Vooght, Federica De Stefano, Carmen Scieuzo, Paul Cos, Patrizia Falabella

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Emine DerinDepartment of Basic and Applied Sciences, University of Basilicata, Potenza, Italy.
Laurence Van MollLaboratory for Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium.
Milan WoutersLaboratory for Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium.
Linda De VooghtLaboratory for Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium.
Federica De StefanoDepartment of Basic and Applied Sciences, University of Basilicata, Potenza, Italy.
Carmen ScieuzoDepartment of Basic and Applied Sciences, University of Basilicata, Potenza, Italy.
Paul CosLaboratory for Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium. paul.cos@uantwerpen.be.
Patrizia FalabellaDepartment of Basic and Applied Sciences, University of Basilicata, Potenza, Italy. patrizia.falabella@unibas.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial resistance represents a significant global health challenge, implicated in nearly 5 million deaths per year. This study investigates the antimicrobial properties of selected peptides derived from the Black Soldier Fly (BSF), identified in silico. Ten synthesized peptides were evaluated in vitro against Gram-positive bacteria (Staphylococcus aureus, Bacillus cereus), Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), and fungi (Aspergillus fumigatus, Candida albicans ). Cytotoxicity was assessed using human lung fibroblasts and red blood cells. Among the peptides, Hill_BB_C7176 demonstrated broad-spectrum antibacterial activity, no cytotoxicity and low hemolytic activity (IC₅₀: 31.6 - >32 µM). The peptide displayed rapid bactericidal activity achieving complete eradication at 8× its minimal inhibitory concentration. Propidium iodide uptake increased in a concentration dependent manner, indicating membrane permeabilization contributing to antibacterial activity. In addition, Hill_BB_C7176 exhibited strong binding affinity to lipopolysaccharide (lipid A). In vivo, Hill_BB_C7176 improved survival of Galleria mellonella larvae infected with S. aureus and E. coli, showing similar survival outcomes to reference antibiotics under the experimental conditions tested. These findings highlight the antibacterial potential of BSF-derived antimicrobial peptides, particularly Hill_BB_C7176, supporting the further research on the antibacterial activity of BSF antimicrobial peptides.

Indexed as

Anti-Bacterial AgentsAntimicrobial PeptidesDipteraAnimalsCandida albicansErythrocytesFibroblastsHumansMicrobial Sensitivity TestsAnti-Bacterial AgentsAntimicrobial PeptidesAntibacterial activityAntimicrobial peptidesBlack Soldier FlyDefensin

Identifiers

PMID41735465
PMCPMC13031288

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.