ArticleNature communications2026
Photoelectrocatalytic-microbial biohybrid for succinic acid synthesis.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
4 authors.
Funding
Abstract
Succinic acid is an important platform chemical traditionally produced via energy-intensive and environmentally unfriendly processes. Actinobacillus succinogenes offers a sustainable biosynthetic route, yet its productivity is constrained by limited intracellular electron transfer. Here, we develop a photoelectrocatalytic-microbial biohybrid system to overcome these metabolic bottlenecks. Adaptive laboratory evolution using gold nanoparticles establishes an enhanced charge-transfer pathway in Actinobacillus succinogenes, which is subsequently immobilized on a layer-by-layer NiO@PAA@NHS (NiO nanosheets coated with hydrogel of poly acrylic acid (PAA) grafted with N-Hydroxysuccinimide (NHS)) photoelectrode to construct a NiO@PAA@NHS/Au@ Actinobacillus succinogenes biohybrid. Under simulated solar illumination at -0.3 V vs. RHE, the system delivers a photocurrent density of 1.9 mA cm
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