Evidence map›Paper›PMID 41735308›Full record

ArticleNature communications2026

Disruption of tRNA threonylation triggers RIG-I mediated anti-tumour immune response.

Cléa Dziagwa, Christian Seca, Coralie Capron, Chloe Maurizy, Ning An, Denis Heusdens, Timothy Budden, Lorena Martin-Morales, Miguel Susaeta Ruiz, Elodie Renaude and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Cléa DziagwaLaboratory of Cancer Signaling, GIGA-Institute, University of Liège, Liège, Belgium.
Christian Seca *Laboratory of Cancer Signaling, GIGA-Institute, University of Liège, Liège, Belgium.
Coralie Capron *Laboratory of Cancer Stemness, GIGA-Institute, University of Liège, Liège, Belgium.ORCID http://orcid.org/0000-0001-8922-3101
Chloe MaurizyLaboratory of Cancer biology, GIGA-Institute, University of Liège, Liège, Belgium.
Ning AnLaboratory of Cancer Signaling, GIGA-Institute, University of Liège, Liège, Belgium.
Denis HeusdensLaboratory of Metabolic Regulation, GIGA-Institute, University of Liège, Liège, Belgium.
Timothy BuddenSkin Cancer and Ageing Lab, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.
Lorena Martin-MoralesLaboratory of Cancer Stemness, GIGA-Institute, University of Liège, Liège, Belgium.ORCID http://orcid.org/0000-0002-1970-8872
Miguel Susaeta RuizLaboratory of Cancer Signaling, GIGA-Institute, University of Liège, Liège, Belgium.ORCID http://orcid.org/0009-0002-6445-9809
Elodie RenaudeLaboratory of Metabolic Regulation, GIGA-Institute, University of Liège, Liège, Belgium.
Najla El-HachemLaboratory of Cancer Signaling, GIGA-Institute, University of Liège, Liège, Belgium.ORCID http://orcid.org/0000-0002-4180-3016
Raphael VanleyssemLaboratory of Cancer Signaling, GIGA-Institute, University of Liège, Liège, Belgium.
Marine LeclercqLaboratory of Cancer Signaling, GIGA-Institute, University of Liège, Liège, Belgium.ORCID http://orcid.org/0000-0002-3974-0060
Arnaud BlommeLaboratory of Metabolic Regulation, GIGA-Institute, University of Liège, Liège, Belgium.ORCID http://orcid.org/0000-0003-4183-8726
Alain ChariotLaboratory of Cancer biology, GIGA-Institute, University of Liège, Liège, Belgium.ORCID http://orcid.org/0000-0002-1691-4347
Jochen UtikalSkin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Amaya VirosSkin Cancer and Ageing Lab, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0001-5177-5015
Francesca RapinoLaboratory of Cancer Stemness, GIGA-Institute, University of Liège, Liège, Belgium.
Sylvain DelaunayLaboratory of Cancer Signaling, GIGA-Institute, University of Liège, Liège, Belgium.
Pierre CloseLaboratory of Cancer Signaling, GIGA-Institute, University of Liège, Liège, Belgium. Pierre.Close@uliege.be.ORCID http://orcid.org/0000-0002-8844-9616

Funding

Stichting Tegen Kanker (Belgian Foundation Against Cancer) 2020-068; 2024-148
6 · The paper itself

Abstract

Tumour-induced mechanisms of immune evasion hinder immune response to cancer, particularly in melanoma. mRNA translation, by ensuring accurate protein synthesis, regulates cancer phenotypes and immune response, but the underlying mechanisms remain unclear. Here, we reveal how O-sialoglycoprotein endopeptidase (OSGEP), catalysing the tRNA modification N

Indexed as

DEAD Box Protein 58MelanomaReceptors, ImmunologicRNA, TransferAdenosineAnimalsCell Line, TumorHumansIntegrated Stress ResponseMiceProtein BiosynthesisStress GranulesT-LymphocytesAdenosineDEAD Box Protein 58Receptors, ImmunologicRIGI protein, humanRNA, Transfer

Identifiers

PMID41735308
PMCPMC13043769

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.