Evidence map›Paper›PMID 41735287›Full record

ArticleNature communications2026

Maintenance of intestinal CX3CR1

Stéphane Hua, Keltouma Benmeziane, Delphine Desjardins, Nastasia Dimant, Marco Leonec, Laetitia Bossevot, Julien Lemaitre, Adeline Mélard, Francis Relouzat, Véronique Avettand-Fenoël and 4 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Stéphane HuaUniversité Paris-Saclay, Inserm, CEA; Immunological diseases, microbiology and innovative therapies (IDMIT/UMRS1184), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.
Keltouma BenmezianeUniversité Paris-Saclay, Inserm, CEA; Immunological diseases, microbiology and innovative therapies (IDMIT/UMRS1184), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.
Delphine DesjardinsUniversité Paris-Saclay, Inserm, CEA; Immunological diseases, microbiology and innovative therapies (IDMIT/UMRS1184), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.ORCID http://orcid.org/0000-0002-5820-3914
Nastasia DimantUniversité Paris-Saclay, Inserm, CEA; Immunological diseases, microbiology and innovative therapies (IDMIT/UMRS1184), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.ORCID http://orcid.org/0009-0004-3252-4789
Marco LeonecUniversité Paris-Saclay, Inserm, CEA; Immunological diseases, microbiology and innovative therapies (IDMIT/UMRS1184), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.
Laetitia BossevotUniversité Paris-Saclay, Inserm, CEA; Immunological diseases, microbiology and innovative therapies (IDMIT/UMRS1184), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.ORCID http://orcid.org/0000-0002-5752-9277
Julien LemaitreUniversité Paris-Saclay, Inserm, CEA; Immunological diseases, microbiology and innovative therapies (IDMIT/UMRS1184), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.ORCID http://orcid.org/0000-0001-6239-0110
Adeline MélardUniversité Paris Cité; INSERM, U1016; CNRS, Paris, France.ORCID http://orcid.org/0000-0003-1207-0201
Francis RelouzatUniversité Paris-Saclay, Inserm, CEA; Immunological diseases, microbiology and innovative therapies (IDMIT/UMRS1184), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.ORCID http://orcid.org/0000-0002-6387-8481
Véronique Avettand-FenoëlUniversité Paris Cité; INSERM, U1016; CNRS, Paris, France.ORCID http://orcid.org/0000-0002-7022-2990
Nathalie Dereuddre-BosquetUniversité Paris-Saclay, Inserm, CEA; Immunological diseases, microbiology and innovative therapies (IDMIT/UMRS1184), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.ORCID http://orcid.org/0000-0001-6682-6313
Asier Sáez-CiriónInstitut Pasteur, Université Paris Cité, Viral Reservoirs and Immune Control Unit, Paris, France.ORCID http://orcid.org/0000-0003-2406-7536
Roger Le GrandUniversité Paris-Saclay, Inserm, CEA; Immunological diseases, microbiology and innovative therapies (IDMIT/UMRS1184), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France.ORCID http://orcid.org/0000-0002-4928-4484
Mariangela CavarelliUniversité Paris-Saclay, Inserm, CEA; Immunological diseases, microbiology and innovative therapies (IDMIT/UMRS1184), Fontenay-aux-Roses & Le Kremlin-Bicêtre, France. mariangela.cavarelli@cea.fr.ORCID http://orcid.org/0000-0002-8468-0263

Funding

Sidaction na
6 · The paper itself

Abstract

Achieving durable viral remission without antiretroviral therapy (ART) remains a central challenge in HIV-1 cure research. Using a pathogenic SIV model in male cynomolgus macaques, we investigated mucosal and systemic immune features associated with post-treatment control (PTC). Chronic SIV infection disrupts intestinal macrophage homeostasis, skewing the compartment toward a CX3CR1

Indexed as

CX3C Chemokine Receptor 1MacrophagesReceptors, ChemokineSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusAnimalsCD4-Positive T-LymphocytesCytokinesHomeostasisIntestinal MucosaLymphocyte ActivationMacaca fascicularisMaleViral LoadCX3C Chemokine Receptor 1CytokinesReceptors, Chemokine

Identifiers

PMID41735287
PMCPMC13039934

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.