Evidence map›Paper›PMID 41735281›Full record

ArticleNature communications2026

Combination of PARP and KRAS

Xin Xu, Xin Chen, Rongli Xu, Zhenyu Huo, Changying Li, Somaira Nowsheen, Khaled Aziz, Fan Yao, Zhenkun Lou, Min Deng

Erratum issuedAbstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Targeted therapeutic strategies forTranslational lung cancer research · 2026
    Review
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Xin XuState Key Laboratory of Molecular Oncology and Department of Radiation Oncology, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.ORCID http://orcid.org/0000-0001-8838-6646
Xin ChenState Key Laboratory of Molecular Oncology and Department of Radiation Oncology, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Rongli XuState Key Laboratory of Molecular Oncology and Department of Radiation Oncology, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zhenyu HuoState Key Laboratory of Molecular Oncology and Department of Radiation Oncology, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Changying LiState Key Laboratory of Molecular Oncology and Department of Radiation Oncology, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Somaira NowsheenDepartment of Dermatology, University of California San Diego, San Diego, CA, 92122, USA.ORCID http://orcid.org/0000-0001-7174-5366
Khaled AzizDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, 21231, USA.
Fan YaoHubei Hongshan Laboratory, College of Biomedicine and Health, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, 430070, China. fyao@mail.hzau.edu.cn.ORCID http://orcid.org/0000-0002-4393-7296
Zhenkun LouDepartment of Oncology, Mayo Clinic, Rochester, MN, USA. lou.zhenkun@mayo.edu.ORCID http://orcid.org/0000-0003-1938-3091
Min DengState Key Laboratory of Molecular Oncology and Department of Radiation Oncology, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. dengmin@cicams.ac.cn.ORCID http://orcid.org/0000-0003-1987-9775

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82272757
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy driven predominantly by KRAS mutations, with KRAS

Indexed as

Carcinoma, Pancreatic DuctalPancreatic NeoplasmsPoly(ADP-ribose) Polymerase InhibitorsProto-Oncogene Proteins p21(ras)AnimalsBRCA1 ProteinCD8-Positive T-LymphocytesCell Line, TumorFemaleHumansMiceMutationPhthalazinesPiperazinesPoly(ADP-ribose) PolymerasesRad51 RecombinaseBRCA1 ProteinKRAS protein, humanolaparibPhthalazinesPiperazinesPoly(ADP-ribose) Polymerase InhibitorsPoly(ADP-ribose) PolymerasesProto-Oncogene Proteins p21(ras)RAD51 protein, humanRad51 Recombinasetalazoparib

Identifiers

PMID41735281
PMCPMC13043926

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.