Evidence map›Paper›PMID 41735265›Full record

ArticleNature communications2026

Bifidobacterium longum and prebiotic interventions restore early-life high-fat/high-sugar diet-induced alterations in feeding behavior in adult mice.

Cristina Cuesta-Marti, Eduardo Ponce-España, Friederike Uhlig, Iris Stoltenborg, Luiza A Wasiewska, Lamiah Kareem, Dara Hedayatpour, Loreto Olavarría-Ramírez, Cristina Rosell-Cardona, Thomaz F S Bastiaanssen and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Cristina Cuesta-MartiDepartment of Anatomy and Neuroscience, University College Cork, Cork, Ireland. CCuestaMarti@ucc.ie.ORCID 0000-0001-5801-9394
Eduardo Ponce-España *Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.ORCID 0000-0001-6197-0041
Friederike Uhlig *Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.ORCID 0000-0001-7441-1951
Iris StoltenborgDepartment of Physiology/Endocrine, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Luiza A WasiewskaAPC Microbiome Ireland, Cork, Ireland.
Lamiah KareemAPC Microbiome Ireland, Cork, Ireland.
Dara HedayatpourAPC Microbiome Ireland, Cork, Ireland.
Loreto Olavarría-RamírezDepartment of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
Cristina Rosell-CardonaAPC Microbiome Ireland, Cork, Ireland.ORCID 0000-0003-3627-9413
Thomaz F S BastiaanssenAPC Microbiome Ireland, Cork, Ireland.ORCID 0000-0001-6891-734X
Gabriel S S TofaniDepartment of Anatomy and Neuroscience, University College Cork, Cork, Ireland.ORCID 0009-0008-5140-1628
Benjamin ValderramaDepartment of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
Klara VlckovaAPC Microbiome Ireland, Cork, Ireland.
Suzanne L DicksonDepartment of Physiology/Endocrine, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Aonghus LavelleDepartment of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
Catherine StantonAPC Microbiome Ireland, Cork, Ireland.ORCID 0000-0002-6724-7011
R Paul RossAPC Microbiome Ireland, Cork, Ireland.ORCID 0000-0003-4876-8839
John F CryanDepartment of Anatomy and Neuroscience, University College Cork, Cork, Ireland.ORCID 0000-0001-5887-2723
Timothy G DinanAPC Microbiome Ireland, Cork, Ireland.ORCID 0000-0002-2316-7220
Gerard ClarkeAPC Microbiome Ireland, Cork, Ireland.ORCID 0000-0001-9771-3979
Siobhain M O'MahonyDepartment of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
Harriët SchellekensDepartment of Anatomy and Neuroscience, University College Cork, Cork, Ireland. h.schellekens@ucc.ie.ORCID 0000-0002-6065-3797

Funding

Science Foundation Ireland (SFI) 22/PATH-S/10882Universidad de Sevilla (University of Seville) VI PPIT-US
6 · The paper itself

Abstract

An unhealthy diet disrupts feeding behavior and the gut microbiota, but whether early-life dietary effects persist, or can be restored later in life, remains unclear. We investigated whether microbiota-targeted interventions (FOS + GOS or Bifidobacterium longum APC1472) could restore early-life high-fat/high-sugar (HFHS) diet-induced feeding alterations in adult female and male mice. HFHS exposure exclusively in early-life induced persistent, sex-specific feeding alterations in adult mice, despite normalized body weight. Early-life HFHS diet reduced hypothalamic cells expressing feeding-related markers (POMC, GHSR, PNOC, NOD2) in adult mice. Females were more vulnerable, with reduced LEPR

Indexed as

Bifidobacterium longumDietary SugarsDiet, High-FatFeeding BehaviorGastrointestinal MicrobiomePrebioticsAnimalsFemaleHypothalamusMaleMiceMice, Inbred C57BLDietary SugarsPrebiotics

Identifiers

PMID41735265
PMCPMC12932662

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.