ArticleNature communications2026
Highly selective and practical hydrogenation of functionalized (hetero)arenes.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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13 authors.
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Abstract
Arenes, and particularly heteroarenes are integral structural components of a variety of chemicals and represent a privileged class of bioactive compounds found in pharmaceuticals, agrochemicals and vitamins. Diastereoselective hydrogenation of multi-substituted (hetero)arenes offers an efficient and industrially relevant approach to convert these compounds into valuable, diversified 3D building blocks for applications for example in drug innovation. We show that a rationally designed Pt catalyst permits the general diastereoselective hydrogenation of a broad range of multi-substituted and functionalized arenes and heteroarenes using mild conditions. The corresponding cyclic products are obtained with very high diastereoselectivity (d.r. value up to 99/1). The practical applicability of this catalysis is illustrated by the straightforward preparation of a novel plasticizer on kg-scale under solvent-free conditions.
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