ArticleJournal for immunotherapy of cancer2026
Commentary on "Comparative efficacy and safety of PSCA CAR-engineered Vδ1 γδ T cells for immunotherapy of pancreatic cancer".
Article in Journal for immunotherapy of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Adoptive transfer of unmodified γδ T cells has shown limited clinical benefit, prompting a shift toward chimeric antigen receptor (CAR) engineering to enhance activation, persistence, and tumor specificity. CAR technology positions γδ T cells as promising carriers due to their innate-like cytotoxicity and HLA-independent recognition. Evidence from αβ CAR T-cell trials indicates that γδ CAR T cells can persist for months to years post-infusion, suggesting their potential contribution to long-term immune surveillance against cancer. Among γδ subsets, Vγ9Vδ2 T cells dominate peripheral blood and have been preferentially used for CAR engineering. Recent advances, however, enable the expansion of Vδ1 T cells, known for their tissue residency and resistance to exhaustion. In a key comparative study, Li
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