Trial reportYonsei medical journal2026
14-day Empirical Therapy Compared with 7-day Tailored Therapy for
Trial report in Yonsei medical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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11 authors.
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Abstract
purposeThere are ongoing debates regarding whether tailored therapy based on genotypic resistance can reduce treatment duration compared to empirical therapy. This study was a nationwide, multi-center, randomized trial conducted in Korea to compare the efficacy of 14-day empirical therapy with 7-day tailored therapy as a first-line treatment for MATERIALS AND
methodsPatients were randomized to receive either 14-day empirical therapy or 7-day tailored therapy based on genotypic resistance. The empirical therapy consisted of a clarithromycin-based triple therapy (TT) regimen (twice-daily doses of pantoprazole 40 mg, amoxicillin 1 g, and clarithromycin 500 mg). Tailored therapy involved a 7-day TT in patients without genotypic resistance, while those with resistance received a 7-day bismuth quadruple therapy regimen (twice-daily doses of pantoprazole 40 mg, three-times-daily doses of metronidazole 500 mg, and four-times-daily doses of bismuth 300 mg and tetracycline 500 mg). Eradication rates were assessed using the ¹³C-urea breath test. The primary outcome was the eradication rate in each group.
resultsA total of 102 patients were enrolled. In the intention-to-treat analysis, eradication rates were 65.5% in the empirical therapy group and 82.9% in the tailored therapy group (
conclusionThis study demonstrated that tailored therapy based on genotypic resistance may reduce treatment duration compared to empirical therapy in the eradication of
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