Evidence map›Paper›PMID 41734601›Full record

Trial reportAutonomic neuroscience : basic & clinical2026

Elevating blood pressure in neurogenic orthostatic hypotension: Investigating the efficacy and tolerability of rebreathing therapy.

Jacquie R Baker, Shaun I Ranada, Anthony V Incognito, Robert S Sheldon, Carlos A Morillo, Richard J A Wilson, Aaron A Phillips, Satish R Raj

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Autonomic neuroscience : basic & clinical, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05295810 (Investigating Hypercapnia to Treat Neurogenic Orthostatic Hypotension), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05295810 narecruitingnot on this map

Investigating Hypercapnia to Treat Neurogenic Orthostatic Hypotension

TypeinterventionalSponsorUniversity of CalgaryRan2022 to 2030Enrolled80ConditionsOrthostatic Hypotension, Neurogenic Orthostatic HypotensionArmsSequential Gas Delivery
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jacquie R BakerDepartment of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
Shaun I RanadaDepartment of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada.
Anthony V IncognitoDepartment of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; Cardiovascular and Renal Sciences, Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, Canada.
Robert S SheldonDepartment of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada.
Carlos A MorilloDepartment of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada.
Richard J A WilsonDepartment of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; Alberta Children's Hospital Research Institute for Child and Maternal Health, University of Calgary, Calgary, Alberta, Canada.
Aaron A PhillipsDepartment of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
Satish R RajDepartment of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada; Vanderbilt Autonomic Dysfunction Center, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: satish.raj@ucalgary.ca.

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
NCATS NIH HHS UL1 TR000445
6 · The paper itself

Abstract

purposeNeurogenic orthostatic hypotension (nOH) causes profound drops in blood pressure (≥20/10 mmHg). We previously showed that carbon dioxide (CO

methodsIn this exploratory sub-study, ten patients with nOH (F = 3; 69 ± 9 years) performed two sit-to-stand tests while breathing either room air or simulated rebreathing. Continuous blood pressure, heart rate, respiration, stroke volume, cardiac output, and systemic vascular resistance were recorded. Hemodynamics were averaged over the final minute of stand for each condition. Tolerability was defined as completing the full 5-minute stand without aborting due to breathing discomfort.

resultsCompared to room air, simulated rebreathing increased standing systolic blood pressure (p = 0.02), stroke volume (p = 0.03), cardiac output (p = 0.02), and reduced hypotensive time (p = 0.02). Hemodynamic responses and hypotensive time during simulated rebreathing did not differ from +CO₂ alone (all p > 0.1). Tolerability was lower with only 2/10 patients completing the simulated rebreathing protocol, primarily due to shortness of breath, whereas 9/10 completed +CO₂ alone (p = 0.014).

conclusionsSimulated rebreathing improves standing blood pressure in nOH but is poorly tolerated. High CO₂ alone appears equally effective and better tolerated. CO₂ delivery systems that elevate CO₂ while maintaining oxygen may offer a more feasible therapeutic strategy. CLINICAL TRIAL NO: NCT05295810 https://clinicaltrials.gov/study/NCT05295810.

Indexed as

Blood PressureCarbon DioxideHypotension, OrthostaticAgedFemaleHeart RateHumansMaleMiddle AgedOxygenTreatment OutcomeCarbon DioxideOxygenAcute blood pressure therapyCarbon dioxide therapyNeurogenic orthostatic hypotensionRebreathing therapy

Identifiers

PMID41734601
PMCPMC13218394

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.