Evidence map›Paper›PMID 41734580›Full record

ArticleRedox biology2026

Sensitive and specific methodology for detection of labile NO-ferroheme complexes in vitro and in blood.

Anthony W DeMartino, David S Mahan, Brendan S Gladwin, Jacob E Correnti, Qinzi Xu, Deborah J Rodriguez, Ruya Liu, Elizabeth R Rochon, Jason J Rose, Daniel B Kim-Shapiro and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Anthony W DeMartinoDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA. Electronic address: ADeMartino@som.umaryland.edu.
David S MahanDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Brendan S GladwinDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Jacob E CorrentiDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Qinzi XuDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Deborah J RodriguezDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Ruya LiuDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Elizabeth R RochonDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Jason J RoseDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Daniel B Kim-ShapiroDepartment of Physics, Wake Forest University, Winston-Salem, NC, 27109, USA; Translational Science Center, Wake Forest University, Winston-Salem, NC, 27109, USA.
Mark T GladwinDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, 21201, USA. Electronic address: MGladwin@som.umaryland.edu.

Funding

Storage Lesion in Banked Blood Due to Disruption of Nitric Oxide HomeostasisR01HL098032 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Mark T Gladwin · 2009 to 2026
$12.5M
Antidote for inhaled CO poisoning based on mutationally engineered neuroglobinR01HL125886 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Mark T Gladwin, Jesus Tejero Bravo · 2015 to 2026
$7.9M
Discovering and Developing Recombinant Molecular Scavenging Agents for the Treatment of Carbon Monoxide Induced Cardiovascular DysfunctionK08HL136857 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROSE, JASON J · 2018 to 2022
$970k
NHLBI NIH HHS K08 HL136857NHLBI NIH HHS R01 HL098032NHLBI NIH HHS R01 HL125886
6 · The paper itself

Abstract

Nitric oxide (NO) is formed via the oxidation of l-arginine in a reaction catalyzed by the NO synthase enzymes or via reduction of inorganic nitrite (NO

Indexed as

HemeNitric OxideAnimalsHumansMiceOxidation-ReductionHemeNitric Oxide

Identifiers

PMID41734580
PMCPMC12950416

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.