ArticleJACC. Advances2026
Association Between Occupational Physical Work Exposure and Wild-Type Transthyretin Cardiomyopathy.
Article in JACC. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Early-Onset Wild-Type Transthyretin Amyloidosis Polyneuropathy.Muscle & nerve · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe incidence of transthyretin wild-type amyloid cardiomyopathy (ATTRwt-CM) is increasing. Previous findings suggest an association between mechanical stress and ATTRwt-CM.
objectivesThis study aimed to assess differences in employment history, occupational mechanical exposures, comorbidity, and mortality between patients with ATTRwt-CM compared with a matched general population cohort.
methodsPatients diagnosed with ATTRwt-CM between 2016 and 2023 were matched 1:5 by age and sex with controls randomly selected from the Danish general population. Outcomes were minimum 3 years of previous agricultural or other general physical demanding employment, predicted median upper and lower body mechanical exposures, and cardiovascular and all-cause mortality. Conditional Poisson regression was used to estimate incidence rate ratios (IRRs).
resultsA total of 258 patients with ATTRwt-CM were matched with 1,290 controls. ATTRwt-CM patients had a higher prevalence of cardiovascular comorbidities (atrial fibrillation and aortic stenosis) and orthopedic conditions (carpal tunnel syndrome, lumbar spinal stenosis, and lower limb arthrosis). Agricultural employment (28% vs 8%; IRR: 3.35; 95% CI: 2.55-4.39) and greater upper body mechanical workload exposures were more common among patients with ATTRwt-CM than among controls. Three-year cardiovascular mortality (13% vs 5%; IRR: 3.38; 95% CI: 1.97-5.83) and all-cause mortality (33% vs 21%; IRR: 1.93; 95% CI: 1.48-2.50) were higher in patients with ATTRwt-CM.
conclusionsATTRwt-CM was associated with greater occupational upper-body mechanical stress. While a causal relationship cannot be established due to study design, the results are hypothesis generating for the development of ATTRwt-CM. Additionally, ATTRwt-CM patients had a greater burden of orthopedic and cardiovascular comorbidities including increased cardiovascular mortality.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.