Evidence map›Paper›PMID 41734072›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Understanding human metacontrol and its pathologies using deep neural networks.

Kai J Sandbrink, Laurence T Hunt, Christopher Summerfield

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Understanding human metacontrol and its pathologies using deep neural networks.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kai J SandbrinkDepartment of Experimental Psychology, University of Oxford, Oxford OX1 3EL, United Kingdom.ORCID 0000-0003-0360-075X
Laurence T HuntDepartment of Experimental Psychology, University of Oxford, Oxford OX1 3EL, United Kingdom.ORCID 0000-0002-8393-8533
Christopher SummerfieldDepartment of Experimental Psychology, University of Oxford, Oxford OX1 3EL, United Kingdom.

Funding

EC | European Research Council (ERC) 725937Ministry of Education (Spain) ATRAE GrantRoyal Society (The Royal Society) Henry Dale FellowshipStiftung Begabtenförderung Cusanuswerk (Foundation for Gifted Cusanuswerk) Doctoral FellowshipUKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BB/W003392/1Wellcome TrustWellcome Trust (WT) 227928/Z/23/Z
6 · The paper itself

Abstract

Error monitoring is crucial for inferring how controllable an environment is, and thus for estimating the value of control processes (metacontrol). In this study, we use computational simulations with deep neural networks to investigate its behavioral and neural correlates. We trained both humans and deep reinforcement learning (RL) agents to perform a reward-guided learning task that required adaptation to changes in action controllability. Deep RL agents could only solve the task when designed to explicitly predict action prediction errors that fire in the medial prefrontal cortex. When trained this way, they displayed signatures of metacontrol that closely resembled those observed in humans. Moreover, when deep RL agents were trained to over- or underestimate controllability, they developed behavioral pathologies partially matching those of humans who reported depressive, anxious, or compulsive traits on transdiagnostic questionnaires. These findings open up avenues for studying metacontrol using deep neural networks.

Indexed as

Deep LearningNeural Networks, ComputerComputer SimulationHumansPrefrontal CortexReinforcement Machine LearningRewardcognitive controlerror monitoringmetacontrolpsychopathologyreinforcement learning

Identifiers

PMID41734072
PMCPMC12956855

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.