Evidence map›Paper›PMID 41734006›Full record

ArticleRespiratory care2026

Postextubation Arterial Blood Gas to Predict Reintubation in Children With Congenital Heart Disease.

Andrew G Miller, Katherine Cashen, Elizabeth J Thompson, Joseph Zakhar, Rachel M Watts, Veerajalandhar Allareddy, Anna Fritz, Alexandre T Rotta

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Andrew G MillerMr. Miller, Dr. Cashen, Dr. Thompson, Dr. Zakhar, Dr. Allareddy, and Dr. Rotta are affiliated with the Division of Pediatric Critical Care Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Katherine CashenMr. Miller, Dr. Cashen, Dr. Thompson, Dr. Zakhar, Dr. Allareddy, and Dr. Rotta are affiliated with the Division of Pediatric Critical Care Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Elizabeth J ThompsonMr. Miller, Dr. Cashen, Dr. Thompson, Dr. Zakhar, Dr. Allareddy, and Dr. Rotta are affiliated with the Division of Pediatric Critical Care Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Joseph ZakharMr. Miller, Dr. Cashen, Dr. Thompson, Dr. Zakhar, Dr. Allareddy, and Dr. Rotta are affiliated with the Division of Pediatric Critical Care Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Rachel M WattsMr. Miller is affiliated with the Respiratory Care Services, Duke University Medical Center, Durham, North Carolina, USA.
Veerajalandhar AllareddyMr. Miller, Dr. Cashen, Dr. Thompson, Dr. Zakhar, Dr. Allareddy, and Dr. Rotta are affiliated with the Division of Pediatric Critical Care Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Anna FritzMs. Fritz is affiliated with the Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
Alexandre T RottaMr. Miller, Dr. Cashen, Dr. Thompson, Dr. Zakhar, Dr. Allareddy, and Dr. Rotta are affiliated with the Division of Pediatric Critical Care Medicine, Duke University Medical Center, Durham, North Carolina, USA.

Funding

Real-world Data Enables Pharmacokinetic/Pharmacodynamic-based Drug Dosing in Critically Ill ChildrenK23HD116971 · NICHD · DUKE UNIVERSITY · PI Elizabeth Jaclyn Thompson · 2025 to 2026
$375k
NICHD NIH HHS K23 HD116971
6 · The paper itself

Abstract

backgroundChildren with cardiac disease frequently receive mechanical ventilation. Drawing an arterial blood gas (ABG) 1-2 h postextubation is common practice. Limited data exist evaluating the utility of ABGs in this context. We hypothesized that postextubation acidemia would be associated with reintubation.

methodsWe retrospectively evaluated all patients with an ABG postextubation in the pediatric cardiac intensive care unit (PCICU) between June 2022 and December 2024. We defined acidemia as an arterial pH <7.35. Our primary outcome was reintubation within 48 h. Secondary outcomes included duration of noninvasive respiratory support (NRS) and hospital stay.

resultsWe studied 718 subjects, and 91 (13%) had acidemia. Subjects with postextubation acidemia were more likely to be reintubated (21% vs 7.3%,

conclusionsEighty percent of subjects with postextubation acidemia did not require reintubation, but acidemia was associated with a 3-fold increased risk of reintubation.

Indexed as

AcidosisAirway ExtubationBlood Gas AnalysisHeart Defects, CongenitalIntubation, IntratrachealChildChild, PreschoolFemaleHumansInfantIntensive Care Units, PediatricLength of StayMaleRetrospective Studiesblood gaschildrencongenital heart diseaseextubationnoninvasive respiratory support

Identifiers

PMID41734006
PMCPMC13579538

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.