Evidence map›Paper›PMID 41733902›Full record

ArticleOrganic letters2026

Cyclover-Assisted Liquid-Phase Peptide Synthesis Using T3P® as a Green Coupling Reagent.

Priyanka Kushwaha, Marvin Mantel, Peter Talbiersky, Yongfu Li, Anamika Sharma, Beatriz G de la Torre, Fernando Albericio

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Priyanka KushwahaPeptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Westville, Durban 4000, South Africa.
Marvin MantelCuria Germany GmbH, Industriepark Höchst D569, 65926 Frankfurt am Main, Germany.ORCID 0000-0002-3541-3388
Peter TalbierskyCuria Germany GmbH, Industriepark Höchst D569, 65926 Frankfurt am Main, Germany.
Yongfu LiBiotide Core, LLC, 33815 SE Eastgate Circle, Corvallis, Oregon 97333, United States.
Anamika SharmaPeptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Westville, Durban 4000, South Africa.ORCID 0000-0003-1282-5838
Beatriz G de la TorrePeptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Westville, Durban 4000, South Africa.ORCID 0000-0001-8521-9172
Fernando AlbericioPeptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Westville, Durban 4000, South Africa.ORCID 0000-0002-8946-0462

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liquid-phase peptide synthesis (LPPS) continues to evolve toward more sustainable and efficient methodologies. In this study, we introduce Cyclover as a tag that enables efficient, tunable LPPS in 2Me-THF using propylphosphonic anhydride (T3P®) as a coupling reagent. The extraction protocol reduces the PMI ∼2.7-fold while maintaining high purity and isolated yield, offering a greener and versatile route to complex peptides.

Indexed as

AnhydridesOrganophosphonatesPeptidesGreen Chemistry TechnologyIndicators and ReagentsMolecular StructureAnhydridesIndicators and ReagentsOrganophosphonatesPeptides

Identifiers

PMID41733902
PMCPMC12973291

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.