ArticleBrain and behavior2026
Shared Genetic Basis and Causality Between Epilepsy and Psychiatric Disorders: Evidence From a Comprehensive Genetic Analysis.
Article in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Concomitant pathologies and their impact on schizophrenia: a narrative overview of current evidence.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
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3 authors.
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Abstract
backgroundGrowing evidence suggests that epilepsy and psychiatric disorders may share common genetic underpinnings, yet the precise etiological relationship remains unclear. Psychiatric comorbidities affect approximately 30% of individuals with epilepsy, a rate markedly higher than in the general population, with depression (∼23%) and anxiety (∼20%) being the most prevalent. This high comorbidity burden not only worsens prognosis but also complicates management, underscoring the need for genetic insights into their relationship. To address this gap, we aimed to systematically evaluate the genetic correlation, pleiotropy, and potential causal associations between epilepsy and 14 major psychiatric disorders.
methodsWe analyzed N million single-nucleotide polymorphisms (SNPs) from genome-wide association study (GWAS) summary statistics of epilepsy and 14 psychiatric disorders. These GWAS data were obtained from large international consortia, primarily comprising individuals of European ancestry. First, we assessed the genetic correlation between epilepsy and 14 psychiatric disorders using Linkage Disequilibrium Score Regression (LDSC). Second, we used Pleiotropic Analysis under the Composite Null Hypothesis (PLACO) to identify pleiotropic loci at the SNP level. Summary genotype-phenotype association statistics were used, excluding SNPs with extreme Z
resultsWe identified a significant genetic link between epilepsy and attention deficit and hyperactivity disorder (ADHD) (r
conclusionsSCZ, ADHD, MDD and epilepsy may share a common etiology, respectively. These etiologies may be related to precise molecular mechanisms, leading to overlapping pathological physiology and clinical features. These findings may offer insights into treatment trials.
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