ReviewMedScience2026
Diffuse large B-cell lymphoma combined with hyperlactatemia presents high mortality: case report and literature review.
Review in MedScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
Funding
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Abstract
Diffuse large B-cell lymphoma (DLBCL) can present with hyperlactatemia or even lactic acidosis (LA) as a rare but often underrecognized complication among hematologists. Patients diagnosed with DLBCL complicated by LA generally exhibit high mortality and a poor prognosis, even with therapeutic intervention. This report details two cases of DLBCL concurrently presenting with LA and provides a literature review. Our analysis of 19 published studies revealed a survival advantage in patients with an initial lactate levels of 5-14.9 mmol/L compared to those with levels of 15-24.9 mmol/L. Furthermore, the maximum lactate level correlated with survival, with higher values predicting shorter survival times. For type B LA, early initiation of chemotherapy-based treatment significantly improved patient survival compared to other treatment approaches (P = 0.026). Adjunctive treatments such as sodium bicarbonate, thiamine, and vitamin B may also be beneficial. Careful attention should also be paid to avoiding medications that can increase lactate levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.