ReviewDigestive diseases and sciences2026
Eosinophilic Ascites: An Underrecognized Entity in Peritoneal Disorders.
Review in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Eosinophilic gastrointestinal diseases.Nature reviews. Disease primers · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEosinophilic ascites (EA) is a rare, under-recognized condition characterized by eosinophil-rich peritoneal fluid, most frequently associated with eosinophilic gastroenteritis (EGE). Its true prevalence is unclear, often misdiagnosed as malignancy, tuberculosis, or cirrhosis. EA typically presents between ages 30 and 50, with slight male predominance. Its clinical importance lies in a favorable response to corticosteroids and the potential for severe complications such as intestinal obstruction if untreated.
objectiveThis review consolidates current knowledge on EA, focusing on its etiology, pathophysiology, diagnostic challenges, and treatment strategies, while highlighting key knowledge gaps.
methodsA narrative review was conducted using PubMed, SpringerLink, and Web of Science (2000-2025). Search terms included "eosinophilic ascites," "eosinophilia," and "ascitic fluid." Included studies reported histopathologically confirmed EA with ascitic eosinophilia > 10%, imaging data, and treatment outcomes. Case reports lacking confirmatory paracentesis or biopsy were excluded. Data on demographics, clinical presentation, fluid analysis, imaging, etiology, treatment, and outcomes were extracted independently by two reviewers.
resultsEA pathogenesis involves IL-5-driven eosinophilic infiltration of the gastrointestinal serosa. Diagnostic features include exudative ascites (protein > 2.5 g/dL) with eosinophilic predominance (60-90%), peripheral eosinophilia (85%), and CT evidence of bowel wall thickening (72%). Corticosteroids (0.5-1 mg/kg/day) achieve remission in 80% within two weeks; anti-IL-5 agents may benefit refractory cases. Significant gaps include absent diagnostic biomarkers and unknown relapse rates.
conclusionEA demands heightened clinical suspicion in eosinophilic ascites. Future priorities include the development of non-invasive diagnostics, trials comparing biologics with steroids, and the exploration of genetic mutations in refractory disease.
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