Evidence map›Paper›PMID 41733718›Full record

ArticleArchives of virology2026

Lineage replacement of coxsackievirus A10 in Vietnam associated with increased detection and altered disease severity grading of hand, foot, and mouth disease.

Anh The Nguyen, Hong Thi Thu Ta, Anh Thi Hai Dao, Hung Manh Vu, Nghia Duy Ngu, Duong Nhu Tran, Hiroyuki Shimizu, Yorihiro Nishimura, Thi Nguyen Hoa-Tran

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In one paragraph

Article in Archives of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Anh The NguyenDepartment of Virology, National Institute of Hygiene and Epidemiology, Ha Noi, Vietnam.
Hong Thi Thu TaDepartment of HIV/AIDS, National Institute of Hygiene and Epidemiology, Ha Noi, Vietnam.
Anh Thi Hai DaoDepartment of Virology, National Institute of Hygiene and Epidemiology, Ha Noi, Vietnam.
Hung Manh VuDepartment of Virology, National Institute of Hygiene and Epidemiology, Ha Noi, Vietnam.
Nghia Duy NguDepartment of Control of Communicable Disease, National Institute of Hygiene and Epidemiology, Ha Noi, Vietnam.
Duong Nhu TranDepartment of Control of Communicable Disease, National Institute of Hygiene and Epidemiology, Ha Noi, Vietnam.
Hiroyuki ShimizuDepartment of Virology II, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo, Japan.
Yorihiro NishimuraDepartment of Virology II, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo, Japan.
Thi Nguyen Hoa-TranDepartment of Virology, National Institute of Hygiene and Epidemiology, Ha Noi, Vietnam. trnghoasuk@gmail.com.ORCID http://orcid.org/0000-0001-6887-7317

Funding

Japan Agency for Medical Research and Development JP20fk0108139Japan Agency for Medical Research and Development JP23fk0108683
6 · The paper itself

Abstract

Coxsackievirus A10 (CV-A10) has become an important cause of hand, foot, and mouth disease (HFMD). Molecular surveillance in northern Vietnam during 2018–2020 revealed the introduction and rapid dominance of the genotype C lineage (CHN), replacing the previously endemic lineage (VNM). This shift was associated with a significant increase in detection and altered clinical severity, predominantly grade 2A (83.8%). Phylogenetic analysis revealed the close relatedness between the emerging Vietnamese strains and those circulating in China (2017–2024). These findings suggest lineage-dependent virulence in CV-A10, highlighting the need for lineage-level molecular surveillance to guide HFMD control and vaccine development.

Indexed as

EnterovirusHand, Foot and Mouth DiseaseGenotypeHumansPhylogenySeverity of Illness IndexVietnam

Identifiers

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.