Evidence map›Paper›PMID 41733685›Full record

ArticleWorld journal of urology2026

Functional and volumetric changes following partial nephrectomy for large (≥ 7 cm) renal masses: a comparative study.

Cheng Luo, Guanghan Zhang, Yixin Huang, Xiaohua Liu, Shaohan Yin, Huiming Liu, Xiangpeng Zou, Xin Luo, Longbin Xiong, Zhaohui Zhou and 12 more

Abstract readComparative Study
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In one paragraph

Article in World journal of urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

22 authors.

Cheng LuoDepartment of Urology, Sun Yat-sen University Cancer Center, Dongfengdonglu 651, Guangzhou, People's Republic of China.
Guanghan ZhangDepartment of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Kangdalu 1, Guangzhou, People's Republic of China.
Yixin HuangDepartment of Urology, Sun Yat-sen University Cancer Center, Dongfengdonglu 651, Guangzhou, People's Republic of China.
Xiaohua LiuState Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
Shaohan YinState Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
Huiming LiuState Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
Xiangpeng ZouDepartment of Urology, Sun Yat-sen University Cancer Center, Dongfengdonglu 651, Guangzhou, People's Republic of China.
Xin LuoDepartment of Urology, Sun Yat-sen University Cancer Center, Dongfengdonglu 651, Guangzhou, People's Republic of China.
Longbin XiongDepartment of Urology, Sun Yat-sen University Cancer Center, Dongfengdonglu 651, Guangzhou, People's Republic of China.
Zhaohui ZhouDepartment of Urology, Sun Yat-sen University Cancer Center, Dongfengdonglu 651, Guangzhou, People's Republic of China.
Yulu PengDepartment of Urology, Sun Yat-sen University Cancer Center, Dongfengdonglu 651, Guangzhou, People's Republic of China.
Xiaofeng YangDepartment of Urology, Sun Yat-sen University Cancer Center, Dongfengdonglu 651, Guangzhou, People's Republic of China.
Lihao ZhangDepartment of Urology, Sun Yat-sen University Cancer Center, Dongfengdonglu 651, Guangzhou, People's Republic of China.
Binglei MaDepartment of Urology, Sun Yat-sen University Cancer Center, Dongfengdonglu 651, Guangzhou, People's Republic of China.
Wensu WeiDepartment of Urology, Sun Yat-sen University Cancer Center, Dongfengdonglu 651, Guangzhou, People's Republic of China.
Fangjian ZhouDepartment of Urology, Sun Yat-sen University Cancer Center, Dongfengdonglu 651, Guangzhou, People's Republic of China.
Hui HanDepartment of Urology, Sun Yat-sen University Cancer Center, Dongfengdonglu 651, Guangzhou, People's Republic of China.
Shengjie GuoDepartment of Urology, Sun Yat-sen University Cancer Center, Dongfengdonglu 651, Guangzhou, People's Republic of China.
Pei DongDepartment of Urology, Sun Yat-sen University Cancer Center, Dongfengdonglu 651, Guangzhou, People's Republic of China.
Guohua ZengDepartment of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Kangdalu 1, Guangzhou, People's Republic of China.
Chunping YuDepartment of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Kangdalu 1, Guangzhou, People's Republic of China. ychp_83@163.com.
Zhiling ZhangDepartment of Urology, Sun Yat-sen University Cancer Center, Dongfengdonglu 651, Guangzhou, People's Republic of China. zhangzhl@sysucc.org.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePartial nephrectomy (PN) has been performed for renal masses ≥7cm with promised oncological outcome, whereas their functional and volumetric changes remain unclear. This study aims to evaluate renal functional and volumetric changes after PN for renal masses ≥7cm and compare these outcomes with those of with smaller renal masses(<7cm).

methodsA total of 107 patients with renal masses ≥7 cm who underwent PN with sufficient data were included. PN patients with renal masses <7 cm were enrolled as controls. The acute ipsilateral renal dysfunction (AIRD) spectrum score, recovery from ischemia and annual ipsilateral renal parenchymal volume (RPV) decrease was used to reflect short, mid, and long-term functional/volumetric changes, respectively.

resultThe median tumor size in the study group was 8cm (interquartile range [IQR]: 7.5-9cm) with a median R.E.A.N.L. score of 10(IQR: 8-10) and the median ischemia time was 30 minutes, which were all significantly higher than those in the control group. Although the study group demonstrated lower ipsilateral renal parenchymal volume preservation (81.5% vs. 88.3%) and GFR preservation(74.6% vs. 84.4%, both p < 0.001), spectrum sore(0.25 vs. 0.21, p=0.2), recovery from ischemia(91.6% vs. 93.8%, p=0.2) and annual ipsilateral RPV decrease(5.5% vs. 3.4%, p=0.3) were comparable between the two groups. The main limitations include a relatively small sample size and limited follow-up duration.

conclusionsCompared with smaller renal masses(<7 cm), PN for masses ≥7 cm was associated with moderately reduced ipsilateral RPV and GFR preservation. However, the severity of acute kidney injury (AKI), mid-term functional recovery, and long-term volumetric changes were not significantly compromised , supporting the feasibility of PN for large renal masses.

Indexed as

Carcinoma, Renal CellKidneyKidney NeoplasmsNephrectomyAgedFemaleGlomerular Filtration RateHumansMaleMiddle AgedOrgan SizeRetrospective StudiesTumor BurdenAcute kidney injuryKidney volumeLarge renal massPartial nephrectomyRenal function

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.