Evidence map›Paper›PMID 41733473›Full record

ArticleRadiology2026

Dynamic MRI of Fluid and Solute Transportation across the Arachnoid Barrier in the Human Meninges.

Yinghao Li, Yuanqi Sun, Adrian Paez, Gaoqiang Xu, Jay J Pillai, Jeffrey J Iliff, Sandeep K Ganji, Linda Knutsson, Peter C M Van Zijl, David O Kamson and 2 more

Abstract read
In one paragraph

Article in Radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yinghao LiF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, 707 N Broadway, Baltimore, MD 21205.ORCID 0000-0001-7972-6573
Yuanqi SunF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, 707 N Broadway, Baltimore, MD 21205.ORCID 0000-0002-2120-9802
Adrian PaezF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, 707 N Broadway, Baltimore, MD 21205.ORCID 0000-0003-0225-4453
Gaoqiang XuF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, 707 N Broadway, Baltimore, MD 21205.ORCID 0000-0002-4375-0966
Jay J PillaiDivision of Neuroradiology, Mayo Clinic College of Medicine and Science, Rochester, Minn.ORCID 0000-0002-8306-7192
Jeffrey J IliffDepartment of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Wash.ORCID 0000-0002-6910-0080
Sandeep K GanjiF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, 707 N Broadway, Baltimore, MD 21205.ORCID 0000-0002-0247-7596
Linda KnutssonF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, 707 N Broadway, Baltimore, MD 21205.ORCID 0000-0002-4263-113X
Peter C M Van ZijlF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, 707 N Broadway, Baltimore, MD 21205.
David O KamsonDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, Md.
Peter A CalabresiDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, Md.ORCID 0000-0002-7776-6472
Jun HuaF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, 707 N Broadway, Baltimore, MD 21205.ORCID 0000-0001-5481-7380

Funding

University of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI Thomas J. Grabowski · 2020 to 2026
$29.0M
Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in AutismP50HD103538 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI S. Ali Fatemi, Bradley L Schlaggar · 2020 to 2026
$9.9M
TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Hanzhang Lu, Peter CM Van Zijl · 2021 to 2026
$9.9M
Translational Neuroscience CoreU54HD079123 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI FATEMI, S. ALI, SCHLAGGAR, BRADLEY L · 2014 to 2019
$7.9M
Advanced MR Imaging of Olfactory Impairment in Prodromal Alzheimer's DiseaseR01AG064093 · NIA · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI BAKKER, ARNOLD, HUA, JUN · 2020 to 2024
$3.9M
Advanced MRI Studies of Cerebrovascular and Lymphatic Abnormalities in LRRK2 mouse models of Parkinson's diseaseR01NS120879 · NINDS · JOHNS HOPKINS UNIVERSITY · PI HUA, JUN, SMITH, WANLI W · 2021 to 2025
$3.5M
Imaging small blood and lymphatic vessel abnormalities of the olfactory system in schizophreniaR01NS108452 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI HUA, JUN, KAMATH, VIDYULATA · 2018 to 2022
$3.2M
Role of Sleep Disruption after mTBI as a Driver of Chronic Post-traumatic HeadacheR01NS129573 · NINDS · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · PI Jeffrey J Iliff, Andrew F Russo · 2023 to 2026
$2.4M
Interaction between microvascular function and CSF clearance in Lewy body dementiaRF1AG082257 · NIA · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI HUA, JUN · 2023 to 2023
$2.4M
NIA NIH HHS P30 AG066509NIA NIH HHS R01 AG064093NIA NIH HHS RF1 AG082257NIBIB NIH HHS P41 EB031771NICHD NIH HHS P50 HD103538NICHD NIH HHS U54 HD079123NINDS NIH HHS R01 NS108452NINDS NIH HHS R01 NS120879NINDS NIH HHS R01 NS129573
6 · The paper itself

Abstract

Background The dura mater has a permeable vasculature similar to that of peripheral organs, and is separated from the brain, which is enclosed within the arachnoid barrier. Fluid and solute transport across the arachnoid barrier between the subarachnoid space (SAS) and dura is crucial for brain waste clearance and immune surveillance, but few neuroimaging approaches can capture this dynamic process. Purpose To establish a clinically feasible intravenous gadolinium-based contrast agent (GBCA)-based MRI approach for assessing fluid and solute transport across the arachnoid barrier. Materials and Methods This prospective study was conducted from September 2023 to September 2024 in healthy participants. High-resolution structural MRI was used to identify subregions in the meninges. Dynamic dual spin-echo perfusion (DDSEP) MRI was performed to track GBCA distribution in blood and cerebrospinal fluid (CSF) simultaneously. The spatiotemporal characteristics of fluid and solute transportation across the arachnoid barrier were examined by analyzing GBCA-induced signal intensity changes in the fluid outside (dura) and inside (SAS) the arachnoid barrier in the meninges around the superior sagittal sinus (SSS) and bridging veins (BVs). Mann-Whitney

Indexed as

ArachnoidContrast MediaGadoliniumMagnetic Resonance ImagingMeningesAdultCerebrospinal FluidFemaleHumansMaleProspective StudiesSubarachnoid SpaceContrast MediaGadolinium

Identifiers

PMID41733473
PMCPMC12932956

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.