SynthesisClinical and experimental dental research2026
Effect of Different Sodium Hypochlorite Concentrations on Post Endodontic Pain: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Synthesis in Clinical and experimental dental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effectiveness of intracanal cryotherapy in reducing post-endodontic pain in irreversible pulpitis: a systematic review and meta-analysis.Scientific reports · 2026Pooled it
- Effect of Different Sodium Hypochlorite Concentrations on Post Endodontic Pain: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Clinical and experimental dental research · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of the present systematic review and meta-analysis was to evaluate the effect of different concentrations of sodium hypochlorite (NaOCl) on post-operative pain following root canal treatment. MATERIAL AND
methodsThe current study was conducted according to PRISMA guidelines and registered on PROSPERO (CRD42023451576). The research question was formulated according to PICO strategy and aimed at determining if different concentrations of NaOCl would have influenced post-operative pain in adults following endodontic treatments. A comprehensive literature search was performed manually and through multiple electronic databases, using predefined keywords and MeSH terms. Randomized controlled trials (RCTs) comparing different NaOCl concentrations (< 5% vs. ≥ 5%) and reporting post-operative pain in adults were included. The risk of bias was assessed using the Cochrane RoB 2 tool. Meta-analyses were conducted for pain occurrence at 24, 48, and 72 h post-treatment.
resultsSeven RCTs met the inclusion criteria and were included in the systematic review; moreover, four studies underwent quantitative evaluation (meta-analysis). The results showed no statistically significant difference in post-operative pain between low (< 5%) and high (≥ 5%) NaOCl concentrations at any time point. However, a low concentration of NaOCl seemed to be associated with less pain, significantly in 2 papers and not significantly in 4 articles out 7. Only one study reported the opposite trend.
conclusionWithin the limitations of the present study, no significant differences in post-endodontic pain were found between high and low NaOCl concentrations. However, concentrations < 5% might be associated with less pain incidence. Further well-designed clinical trials with standardized methodologies are needed to provide more conclusive evidence.
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Registered trials
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