Evidence map›Paper›PMID 41733355›Full record

ArticleMicrobiology spectrum2026

Are two really better than one? A retrospective study comparing monotherapy versus combination therapy for

Natalie Harris, Amy Mackowiak, Rebekah H Wrenn, Hui-Jie Lee, Alexander Reed, Alaattin Erkanli, Nicholas A Turner, Rebekah Moehring, Connor R Deri

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Natalie HarrisDepartment of Pharmacy, Duke University Hospital, Durham, North Carolina, USA.ORCID 0009-0004-8223-8553
Amy MackowiakDepartment of Pharmacy, Duke University Hospital, Durham, North Carolina, USA.
Rebekah H WrennDepartment of Pharmacy, Duke University Hospital, Durham, North Carolina, USA.
Hui-Jie LeeBiostatistics & Bioinformatics, Duke University School of Medicine, Durham, North Carolina, USA.
Alexander ReedBiostatistics & Bioinformatics, Duke University School of Medicine, Durham, North Carolina, USA.
Alaattin ErkanliBiostatistics & Bioinformatics, Duke University School of Medicine, Durham, North Carolina, USA.
Nicholas A TurnerDivision of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, USA.
Rebekah MoehringBiostatistics & Bioinformatics, Duke University School of Medicine, Durham, North Carolina, USA.
Connor R DeriDepartment of Pharmacy, Duke University Hospital, Durham, North Carolina, USA.

Funding

Support for QA/QC for Prior Approval ProcessUL1TR002553 · NCATS · DUKE UNIVERSITY · PI LI, JENNIFER S, MCNAMARA, JAMES O. · 2018 to 2023
$58.5M
National Institute of Health Sciences (NIHS) UL1TR002553
6 · The paper itself

Abstract

Management of

Indexed as

Anti-Bacterial AgentsGram-Negative Bacterial InfectionsStenotrophomonas maltophiliaAdultAgedDrug Therapy, CombinationFemaleHumansMaleMiddle AgedRetrospective StudiesAnti-Bacterial Agentscombination therapymonotherapyresistanceStenotrophomonas maltophilia

Identifiers

PMID41733355
PMCPMC13055297

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.