Evidence map›Paper›PMID 41733344›Full record

ArticleJournal of virology2026

The origins and potential cross-species transmission of paramyxoviruses and other RNA viruses between native snakes and invasive Burmese pythons in the Florida Everglades.

Ayusha Shrestha, Jasper W Schwarz, Kurtis H Feng, McKayla M Spencer, Aastha Adhikari, Obed O Amwe, Rita G Sacharia, Bradley O'Hanlon, Thomas Denagamage, Alisia A W Weyna and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ayusha ShresthaDepartment of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.
Jasper W SchwarzSchool of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia.
Kurtis H FengDepartment of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.
McKayla M SpencerFlorida Fish and Wildlife Conservation Commission, Tallahassee, Florida, USA.
Aastha AdhikariDepartment of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.
Obed O AmweDepartment of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.
Rita G SachariaDepartment of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.
Bradley O'HanlonFlorida Fish and Wildlife Conservation Commission, Tallahassee, Florida, USA.
Thomas DenagamageDepartment of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.
Alisia A W WeynaSoutheastern Cooperative Wildlife Disease Study and Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA.
Nicole M NemethSoutheastern Cooperative Wildlife Disease Study and Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA.
Edward C HolmesSchool of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0001-9596-3552
Andrew B AllisonDepartment of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.ORCID 0000-0003-0971-1215

Funding

Fish and Wildlife Foundation of Florida CWT23-22
6 · The paper itself

Abstract

During November-December 2020, a disease outbreak involving eastern mudsnakes ( IMPORTANCE: Although the evolution, molecular biology, and pathogenesis of numerous disease-causing animal paramyxoviruses have been examined extensively, studies on reptilian ferlaviruses-which have been responsible for large-scale mortality events in snakes in managed settings for decades-have lagged significantly. Herein, we document the first recognized ferlavirus disease outbreak in free-ranging snakes and provide new insights on the ferlavirus-specific U protein and reptilian host range that make these viruses unique among the paramyxoviruses. In searching for the potential source of ferlaviruses in nature, we discovered other novel RNA viruses in Burmese pythons, an invasive constrictor species introduced into the Everglades. In addition to extending the known diversity of reptilian viruses, these findings provide new fundamental insights into mammalian virus evolution and highlight the potential dangers of the cross-species transmission of such viruses into native snakes and other wildlife.

Indexed as

BoidaeParamyxoviridaeParamyxoviridae InfectionsRNA VirusesSnakesAnimalsDisease OutbreaksFloridaHost SpecificityPhylogenyalphavirusBurmese pythonEvergladesferlavirushepacivirusinvasive species

Identifiers

PMID41733344
PMCPMC13011470

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.