ArticleDiabetes, obesity & metabolism2026
Pre-Treatment Concerns and Their Association With Functioning and Well-Being During Incretin-Based Therapy: A Cross-Sectional Study.
Article in Diabetes, obesity & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimThis study aims to examine weight-loss history and pre-treatment concerns, and their associations with current functioning and well-being in adults undergoing incretin-based pharmacotherapy for obesity. MATERIALS AND
methodsThis cross-sectional study analysed 411 adults treated with three different incretin-based medications. Demographics, previous weight-loss interventions, barriers to earlier attempts, reasons for initiating incretin therapy, treatment characteristics and Treatment-Related Impact Measure for Weight (TRIM-Weight) total scores were assessed. Associations between specific pre-treatment concerns and functioning and well-being were analysed using univariate models and a multivariable regression model that adjusted for treatment related variables.
resultsParticipants had a median age of 39 years (IQR 33-47), 79.1% were women, and the median BMI was 36.3 kg/m
conclusionAmong retrospectively reported pre-treatment concerns, fear of side effects, treatment costs and injection anxiety were most strongly associated with lower functioning and well-being, whereas moral or psychosocial concerns showed no independent associations after multivariable adjustment.
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