ArticleJournal of the American Heart Association2026
Retinal Microvasculature and Emotional, Behavioral, and Cognitive Outcomes at School Age.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
backgroundThe retinal microvasculature can serve as a window into the intracerebral vasculature, and an adverse retinal microvasculature is linked to neurocognitive disease and psychopathology in adults. We hypothesized that associations of retinal vessel calibers with emotional, behavioral, and cognitive outcomes may be present in school-age children.
methodsThis study among 3866 children was embedded in a population-based cohort study from early fetal life. Retinal microvasculature measurements were obtained from retinal photographs at age 6. At ages 6, 10, and 14, total, internalizing, and externalizing problems and attention-deficit hyperactivity disorder symptoms were measured using the Child Behavior Checklist/6-18. Autism symptoms were assessed by the Social Responsiveness Scale at ages 6 and 14. Estimated full-scale intelligence quotient was assessed using the Wechsler Intelligence Scale for Children-Fifth Edition at age 14.
resultsA 1-SD score wider retinal arteriolar caliber was associated with a -0.034 SD score (95% CI, -0.068 to -0.001;
conclusionsFrom our results, we cannot conclude that retinal vessel calibers at age 6 are associated with emotional, behavioral, and cognitive outcomes at ages 6, 10, and 14. Longitudinal studies with repeated childhood measurements are needed to further explore these associations.
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