ArticleJournal of the American Heart Association2026
Modifiable Lifestyle Factors, Left Atrial Indices, and Atrial Fibrillation.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLeft atrial (LA) size is an important determinant of atrial fibrillation (AF) risk and predicts stroke and death. The relationship between common lifestyle factors, LA characteristics, and relationships with incident AF remain largely unknown.
methodsIn this cohort study, we evaluated 37 701 UK Biobank participants without prevalent AF and with cardiac magnetic resonance imaging data. Body mass index was measured by study personnel, while other lifestyle factors were obtained from baseline questionnaires. Cardiac magnetic resonance imaging was performed using a uniformly applied protocol and analyzed using automated methods to determine LA volumes and emptying fraction (EF).
resultsThe magnetic resonance imaging was performed a median 8.9 (interquartile range, 7.4-10) years after the baseline lifestyle factor assessment. In multivariable analyses, a larger body mass index, greater physical activity intensity, and more alcohol intake were each significantly associated with larger LA volumes and smaller LA EFs. In contrast, cumulative pack-years of smoking were linked to smaller LA volumes and LA EFs. Coffee consumption exhibited no significant associations. Larger LA maximal and minimal volumes and a lower LA EF statistically mediated 25%, 28%, and 26% of the association between an increased body mass index and risk of incident AF, respectively, evaluated in separate models. A lower LA EF mediated 27% of the smoking and AF association.
conclusionsCommon lifestyle factors are associated with unfavorable LA size and function, mediating about a quarter of the AF risk associated with obesity and smoking. Lifestyle-related structural LA changes may contribute to AF risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.