Evidence map›Paper›PMID 41732996›Full record

ArticleEuropean journal of immunology2026

Spatial Profiling of Germinal Centers in Mouse Secondary Lymphoid Organs Using MACSima Imaging Cyclic Staining Technology.

Isabel San Martín Molina, Hanneke Okkenhaug, Simon Walker, Michelle Linterman, Edith Marcial-Juárez

Abstract read
In one paragraph

Article in European journal of immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Isabel San Martín MolinaImaging Facility, Babraham Institute, Babraham Research Campus, Cambridge, UK.ORCID 0000-0002-9962-4934
Hanneke OkkenhaugImaging Facility, Babraham Institute, Babraham Research Campus, Cambridge, UK.
Simon WalkerImaging Facility, Babraham Institute, Babraham Research Campus, Cambridge, UK.
Michelle LintermanImmunology Program, Babraham Institute, Babraham Research Campus, Cambridge, UK.ORCID 0000-0001-6047-1996
Edith Marcial-JuárezImmunology Program, Babraham Institute, Babraham Research Campus, Cambridge, UK.ORCID 0000-0001-9211-2541

Funding

Babraham InstituteBBSRC BBS/E/B/000C0541UKRI Frontier Research EP/X022382/1
6 · The paper itself

Abstract

We developed a 50-plex imaging protocol using the MACSima platform to characterize the microarchitecture of germinal centers in secondary lymphoid tissues. This workflow combines tissue processing, automated cyclic imaging, image preprocessing, and a new analysis method that detects morphological changes in irregularly shaped stromal cells.

Indexed as

B-LymphocytesGerminal CenterImage Processing, Computer-AssistedLymphoid TissueAnimalsMiceStaining and LabelingB cellsfollicular dendritic cellsgerminal centersMACSima imaging cyclic stainingT follicular helper cells

Identifiers

PMID41732996
PMCPMC12930330

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.