ArticleAnnals of clinical and translational neurology2026
Evidence of Iron Accumulation in Cerebral Adrenoleukodystrophy: A Potential Novel Disease Mechanism.
Article in Annals of clinical and translational neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
In this first application of Quantitative Susceptibility Mapping Source Separation to cerebral adrenoleukodystrophy, we uncovered alterations in iron and myelin within lesions and normal appearing white matter. As validation, we demonstrate abnormal iron accumulation in those same compartments within primary brain tissue. A gradient of microglial activation to absence parallels the transition from normal white matter to demyelinated lesion. In perilesional white matter, increases in myelin peroxidation and Acyl-CoA synthetase long-chain family member 4 are observed. Thus, the unifying mechanistic relationship of apoptosis to lipid peroxidation in the presence of iron implicates ferroptosis in the pathogenesis of cerebral adrenoleukodystrophy.
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