Evidence map›Paper›PMID 41732976›Full record

ReviewPhysiological reviews2026

Stomach at the crossroads: nuclear receptor signaling at the interface between what we are and what we eat.

Margarita Divenko, Jason C Mills

Abstract readReview
In one paragraph

Review in Physiological reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Margarita DivenkoSection of Gastroenterology, Department of Medicine, Baylor College of Medicine, Houston, Texas, United States.ORCID 0009-0006-5296-4719
Jason C MillsSection of Gastroenterology, Department of Medicine, Baylor College of Medicine, Houston, Texas, United States.ORCID 0000-0002-0402-4662

Funding

REGULATION OF ATROPHY-INDUCED PROGENITOR CELLS IN THE GASTRIC CORPUSR01DK094989 · NIDDK · WASHINGTON UNIVERSITY · PI Jason C Mills · 2012 to 2026
$6.1M
MECHANISMS OF CHIEF CELL DEDIFFERENTIATIONR01DK105129 · NIDDK · WASHINGTON UNIVERSITY · PI Jason C Mills · 2015 to 2026
$5.4M
Mechanisms Governing Expansion of Embryonic Progenitor Cells (EPCs) inMetaplasiaR01CA239645 · NCI · WASHINGTON UNIVERSITY · PI MILLS, JASON C · 2020 to 2024
$2.1M
The Role of Inflammation in Regulating Gastric MetaplasiaR01DK134531 · NIDDK · SAINT LOUIS UNIVERSITY · PI Richard J DiPaolo · 2023 to 2026
$2.1M
Cancer Prevention and Research Institute of Texas (CPRIT) CPRIT RP210027 - Baylor College of Medicine Comprehensive Cancer Training ProgramCancer Prevention and Research Institute of Texas (CPRIT) RP210027HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK105129HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK134531HHS | NIH | NCI | Division of Cancer Prevention, National Cancer Institute (DCP, NCI) R01CA239645NIDDK NIH HHS R01 DK094989NIDDK NIH HHS R01 DK105129
6 · The paper itself

Abstract

The stomach is home to numerous nuclear receptor transcription factors (NRs) that can respond to food, toxins, and other ingested agents. Conversely, signals secreted from other organs (e.g., hormones) can engage gastric NRs to modulate gastric physiology. Thus, there is a rich potential interface between external and internal signals that gastric NRs might respond to and interpret. Here, we seek to comprehensively review the role of NRs in gastric homeostasis and disease pathogenesis. NRs are evolutionarily conserved proteins that regulate gene transcription by interpreting hormonal and environmental signals. We explore NR roles in normal stomach development, cell fate determination, and responses to dietary compounds and xenobiotics. The last topic is of particular recent importance

Indexed as

Gastric MucosaReceptors, Cytoplasmic and NuclearSignal TransductionStomachAnimalsHumansReceptors, Cytoplasmic and Nuclearandrogenestrogenglucocorticoidretinoidtamoxifen

Identifiers

PMID41732976
PMCPMC13213853

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.