ArticleJournal of clinical periodontology2026
Intra-Tissue Bacteriome and Cellular Profiles in Periodontal Granulation Tissue From Osseous Defects and Extraction Sockets.
Article in Journal of clinical periodontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimTo investigate the intra-tissue bacteriome and cell profiles within periodontal granulation tissue (PGT) for exploring the biological essence and translational potentials. MATERIALS AND
methodsPGT samples were collected from 49 patients with severe periodontitis-including those from osseous defects (GT) during periodontal surgery, extraction sockets (ST) and extracted root surfaces (RT) during tooth extraction-while the excised pocket wall (PT) from surgical sites served as the control for diseased tissues. These samples underwent 16S rRNA sequencing, single-cell sequencing and histological assessment.
resultsGT and PT exhibited periodontal health-associated, commensal-enriched bacteriome profiles, while RT and ST showed worse local periodontal condition, enriched periodontopathogens but depleted commensals. Notably, GT contained a higher proportion of mesenchymal stem cells (MSCs) and fibroblasts while fewer natural killer cells than in PT and ST. Pseudotime trajectory analysis revealed endothelial and epithelial differentiation fates from mesenchymal progenitors across tissues. Moreover, there were less inflammatory infiltration and immunoreactivity of CD4
conclusionsOur findings suggest potential periodontal health-associated features of GT regarding clinical, bacteriome and cellular attributes. Future translational study is warranted to explore GT as an alternative source of MSCs for periodontal regeneration.
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