ArticleHypertension (Dallas, Tex. : 1979)2026
Renal Denervation Improves Hepatic Steatosis in Hypertensive Patients With Metabolic Syndrome.
Mert Tokcan, Mathias Hohl, Carolin Victoria Schneider, Kai Markus Schneider, Philipp Markwirth, Benedikt Bernhard, Bernhard Haring, Lucas Lauder, Jörn Schattenberg, Felix Mahfoud and 2 more
Abstract read
In one paragraphArticle in Hypertension (Dallas, Tex. : 1979), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
12 authors.
Mert TokcanKlinik für Innere Medizin III - Kardiologie, Angiologie und Internistische Intensivmedizin, Saarland University Medical Center and Saarland University, Homburg, Germany (M.T., M.H., P.M., B.B., B.H., S.K., M.B.).ORCID 0009-0004-6059-1671 Mathias HohlKlinik für Innere Medizin III - Kardiologie, Angiologie und Internistische Intensivmedizin, Saarland University Medical Center and Saarland University, Homburg, Germany (M.T., M.H., P.M., B.B., B.H., S.K., M.B.).ORCID 0000-0001-6946-9825 Carolin Victoria SchneiderMedizinische Klinik III, RWTH Aachen University Faculty of Medicine, Aachen, Germany (C.V.S., K.M.S.).ORCID 0000-0002-6728-9246 Kai Markus SchneiderMedizinische Klinik III, RWTH Aachen University Faculty of Medicine, Aachen, Germany (C.V.S., K.M.S.).ORCID 0000-0002-0047-3794 Philipp MarkwirthKlinik für Innere Medizin III - Kardiologie, Angiologie und Internistische Intensivmedizin, Saarland University Medical Center and Saarland University, Homburg, Germany (M.T., M.H., P.M., B.B., B.H., S.K., M.B.).ORCID 0009-0006-5043-8520 Benedikt BernhardKlinik für Innere Medizin III - Kardiologie, Angiologie und Internistische Intensivmedizin, Saarland University Medical Center and Saarland University, Homburg, Germany (M.T., M.H., P.M., B.B., B.H., S.K., M.B.).
Bernhard HaringKlinik für Innere Medizin III - Kardiologie, Angiologie und Internistische Intensivmedizin, Saarland University Medical Center and Saarland University, Homburg, Germany (M.T., M.H., P.M., B.B., B.H., S.K., M.B.).ORCID 0000-0001-6109-431X Lucas LauderDepartment of Cardiology, University Heart Center, University Hospital Basel, Basel, Switzerland (L.L., F.M.).ORCID 0000-0003-1434-9556 Jörn SchattenbergDepartment of Internal Medicine II Saarland University Medical Center, Homburg and Saarland University, Homburg, Germany (J.S.).ORCID 0000-0002-4224-4703 Felix MahfoudDepartment of Cardiology, University Heart Center, University Hospital Basel, Basel, Switzerland (L.L., F.M.).ORCID 0000-0002-4425-549X Saarraaken KulenthiranKlinik für Innere Medizin III - Kardiologie, Angiologie und Internistische Intensivmedizin, Saarland University Medical Center and Saarland University, Homburg, Germany (M.T., M.H., P.M., B.B., B.H., S.K., M.B.).
Michael BöhmKlinik für Innere Medizin III - Kardiologie, Angiologie und Internistische Intensivmedizin, Saarland University Medical Center and Saarland University, Homburg, Germany (M.T., M.H., P.M., B.B., B.H., S.K., M.B.).ORCID 0000-0002-2976-2514 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
backgroundSympathetic overactivity is associated with hepatic steatosis. Renal denervation (RDN) is an approved treatment for uncontrolled hypertension through sympathetic modulation; however, its hepatic effects are unknown. This study aimed to assess the effects of RDN on noninvasive tests for hepatic steatosis.
methodsThis single-center study included patients with uncontrolled hypertension and cardiometabolic comorbidities undergoing RDN (n=32) or a sham procedure (n=10). Noninvasive tests for hepatic steatosis, including the hepatic steatosis index (HSI) and fatty liver index (FLI), were calculated at baseline and follow-up visits. An external cohort from the UK Biobank was used to validate the correlation between proton density fat fraction magnetic resonance imaging scans of the liver and these surrogates.
resultsCompared with the control group, RDN significantly reduced HSI at 3 months (0.4±0.5 versus -1.3±0.3;
conclusionsRDN significantly reduced HSI and FLI in patients with uncontrolled hypertension and cardiometabolic comorbidities, suggesting a potential role of sympathetic modulation in metabolic disorders.
Indexed as
Fatty LiverHypertensionKidneyMetabolic SyndromeSympathectomyAgedFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedTreatment Outcomeblood pressurefatty liverhumanshypertension
Identifiers
PMID41732855
PMCPMC13001895
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