ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026
Rising energetic cost of walking predicts cognitive impairment.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe energetic cost of walking increases with age and is linked to physical function impairment, but its relation to cognitive impairment is unknown.
methodsA total of 687 initially cognitively normal older adults (mean age 74.0 ± 7.2 years, 52% women) underwent repeated walking energy expenditure assessments (V̇O
resultsNinety-one participants (13%) progressed to cognitive impairment. Progressors exhibited a steeper increase in energetic cost than non-progressors (B = 0.13; p = 0.003). Higher baseline cost predicted impairment among adults ≥75 years (hazard ratio [HR] = 1.1, 95% confidence interval [CI] = 1.00 to 1.20, p = 0.039), but not those aged 65 to 74 (HR = 0.91, 95% CI = 0.81 to 1.01, p = 0.089).
conclusionWalking efficiency provides a physiological link between mobility and cognitive health; preserving efficiency may reduce risk of Alzheimer's disease and related dementias.
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