ArticlePeerJ2026
Analysis of the long-term solubility and phases of five different root canal sealers in phosphate buffered saline: an
Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Evaluation of the physicochemical properties and adhesive interface quality of BioRoot Flow and BioRoot RCS endodontic sealers: An in vitro study.Clinical oral investigations · 2026Article
- Five-year clinical outcomes of root canal treatment using a calcium silicate-based sealer in teeth with apical periodontitis: a retrospective cohort study.Clinical oral investigations · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The long-term success of root canal therapy depends substantially on the physicochemical stability of endodontic sealers, particularly their solubility and the development of stable crystalline phases during setting. Tricalcium silicate-based sealers (TSBSs) have shown promising biological properties, yet their reported solubility profiles remain inconsistent, raising concerns regarding degradation, gap formation, and the potential for periapical irritation. This study evaluated and compared the solubility and crystalline phase evolution of five commercially available root canal sealers immersed in phosphate-buffered saline (PBS) over extended time intervals. Methods: Twenty-five disc-shaped specimens ( Results: The solubility values varied markedly among the materials and increased over time for most groups. AHP consistently demonstrated the lowest solubility across all intervals, whereas MTAF and BRCS presented the highest values. XRD analysis revealed distinct crystalline phase patterns for each sealer. AHPBC and CS maintained relatively stable crystalline structures throughout the study period. In contrast, BRCS and MTAF exhibited noticeable fluctuations, and AHP showed high crystallinity initially and after 6 months, indicating greater structural stability. Conclusion: AHP displayed the most favourable physicochemical stability, with minimal solubility and sustained crystallinity. AHPBC and CS also demonstrated stable long-term behaviour, whereas BRCS and MTAF showed greater solubility and structural changes. These findings suggest limitations in the long-term durability of these materials. These findings underscore the importance of sealer selection, particularly when considering long-term stability and the potential impact of material dissolution within the root canal system.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.