Evidence map›Paper›PMID 41732723›Full record

ArticlePeerJ2026

Hippocampal expression of Wnt7a and β-catenin in depression: evidence from chronic unpredictable mild stress.

Zehao Zhang, Jialong Huang, Hongyue Yu, Zi Jun Ji, Zijuan Ding, Yiting Wang, Jinyu Kang, Zhen Li, Zhuxin Sui

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zehao Zhang *College of Clinical Medicine, Qilu Medical University, Zibo, Shandong, China.
Jialong Huang *College of Clinical Medicine, Qilu Medical University, Zibo, Shandong, China.
Hongyue YuCollege of Clinical Medicine, Qilu Medical University, Zibo, Shandong, China.
Zi Jun JiCollege of Medical Imaging, Qilu Medical University, Zibo, Shandong, China.
Zijuan DingCollege of Dentistry, Qilu Medical University, Zibo, Shandong, China.
Yiting WangCollege of Clinical Medicine, Qilu Medical University, Zibo, Shandong, China.
Jinyu KangCollege of Clinical Medicine, Qilu Medical University, Zibo, Shandong, China.
Zhen LiUndergraduate Academic Affairs Office, Qilu Medical University, Zibo, Shandong, China.
Zhuxin SuiSchool of Basic Medical Sciences, Qilu Medical University, Zibo, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study sought to examine the impact of Wnt7a/β-catenin signaling on depressive-like behaviors by using a rodent model subjected to chronic unpredictable mild stress (CUMS). Hippocampal Wnt7a and β-catenin expression levels were analyzed to investigate their mechanistic involvement in depression. Therefore, 20 male Sprague-Dawley rats were randomly allocated to the control or the CUMS experimental groups. The CUMS group underwent a 30-day stress protocol involving randomized stimuli. This study was authorized by the Ethics Committee (approval no. YXLL2022006). Following model establishment, depression-related behavioral phenotypes were quantitatively evaluated using standardized behavioral paradigms, the sucrose preference test (SPT), and the open field test (OFT), targeting core symptom domains such as anhedonia and alterations in locomotor activity. The morphology of hippocampal CA2 and DG area neurons was examined using hematoxylin and eosin staining, while immunofluorescence and Western blotting assessed Wnt7a and β-catenin expression. Western blotting also assessed GSK-3β and p-GSK-3β expression. Results indicated that CUMS rats showed markedly lower SPT indices (

Indexed as

beta CateninDepressionHippocampusStress, PsychologicalWnt ProteinsAnimalsBehavior, AnimalDisease Models, AnimalGlycogen Synthase Kinase 3 betaMaleNeuronsProto-Oncogene ProteinsRatsRats, Sprague-Dawleybeta CateninCtnnb1 protein, ratGlycogen Synthase Kinase 3 betaProto-Oncogene ProteinsWnt7a protein, ratWnt ProteinsChronic unpredictable mild stimulationDepressionHippocampusWnt7aWnt7a/β-catenin signaling cascade

Identifiers

PMID41732723
PMCPMC12925407

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.