Evidence map›Paper›PMID 41732672›Full record

ArticleBioactive materials2026

Glycosaminoglycan-functionalized hydrogels for sustained delivery of tissue inhibitor of metalloproteinase-3 mediating matrix metalloprotease inhibition and extracellular matrix stabilization.

Fabian Junker, Stefan Rupf, Paula Marie Schindler, Cedric Wilden, Mathias Hohl, Gloria Ruiz-Gómez, M Teresa Pisabarro, Selina Wrublewsky, Caroline Bickelmann, Charlotte Berhorst and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Fabian JunkerInstitute of Biophysics, Center of Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, 66421, Homburg, Germany.
Stefan RupfClinic of Operative Dentistry, Saarland University, PharmaScienceHub (PSH), Kirrberger Str. 100, Building 73, 66421, Homburg, Saar, Germany.
Paula Marie SchindlerInstitute of Biophysics, Center of Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, 66421, Homburg, Germany.
Cedric WildenInstitute for Clinical and Experimental Surgery, Saarland University, PharmaScienceHub (PSH), 66421, Homburg, Germany.
Mathias HohlDepartment of Internal Medicine III - Cardiology, Angiology and Intensive Care Medicine, Saarland University Hospital, Saarland University, Homburg, Germany.
Gloria Ruiz-GómezStructural Bioinformatics, BIOTEC Technische Universität Dresden, Tatzberg 47/51, 01307, Dresden, Germany.
M Teresa PisabarroStructural Bioinformatics, BIOTEC Technische Universität Dresden, Tatzberg 47/51, 01307, Dresden, Germany.
Selina WrublewskyInstitute for Clinical and Experimental Surgery, Saarland University, PharmaScienceHub (PSH), 66421, Homburg, Germany.
Caroline BickelmannInstitute for Clinical and Experimental Surgery, Saarland University, PharmaScienceHub (PSH), 66421, Homburg, Germany.
Charlotte BerhorstInstitute of Biophysics, Center of Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, 66421, Homburg, Germany.
Dalia AlansaryMolecular Biophysics, Saarland University, Homburg, Germany.
Ben WielandInstitute of Medical Microbiology and Hygiene, Saarland University, 66421, Homburg, Germany.
Markus BischoffInstitute of Medical Microbiology and Hygiene, Saarland University, 66421, Homburg, Germany.
Poh Soo LeeInstitute of Materials Science, Max Bergmann Center of Biomaterials, Technische Universität Dresden, 01069, Dresden, Germany.
Stephanie MoellerBiomaterials Department, INNOVENT e.V., 07745, Jena, Germany.
Albrecht BergBiomaterials Department, INNOVENT e.V., 07745, Jena, Germany.
Tobias A DanckerMolecular Imaging, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Kirrberger Str. 100, Building 48, 66421, Homburg, Saarland, Germany.
Marcel A LauterbachMolecular Imaging, Center for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Kirrberger Str. 100, Building 48, 66421, Homburg, Saarland, Germany.
Bergita GanseWerner Siemens Foundation Endowed Chair of Innovative Implant Development (Fracture Healing), Clinics and Institutes of Surgery, Saarland University, 66421, Homburg, Germany.
Leticia Prates RomaInstitute of Biophysics, Center of Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, 66421, Homburg, Germany.
Therese SteudterINM-Leibniz Institute for New Materials, Chemistry Department, Saarland University, 66123, Saarbrucken, Germany.
Wolfgang MetzgerDepartment of Trauma, Hand and Reconstructive Surgery, Saarland University, 66421, Homburg, Germany.
Thomas TschernigInstitute of Anatomy and Cell Biology, Saarland University, Homburg, Germany.
Emmanuel AmpofoInstitute for Clinical and Experimental Surgery, Saarland University, PharmaScienceHub (PSH), 66421, Homburg, Germany.
Matthias W LaschkeInstitute for Clinical and Experimental Surgery, Saarland University, PharmaScienceHub (PSH), 66421, Homburg, Germany.
Matthias HannigClinic of Operative Dentistry, Saarland University, PharmaScienceHub (PSH), Kirrberger Str. 100, Building 73, 66421, Homburg, Saar, Germany.
Sandra RotherInstitute of Biophysics, Center of Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, 66421, Homburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Excessive protease activity and impaired tissue regeneration are hallmarks of many disease states. Elevated matrix metalloproteinase-9 (MMP-9) plays a key role in adverse tissue remodeling by excessively degrading extracellular matrix (ECM) components and growth factors. Tissue inhibitor of metalloproteinase-3 (TIMP-3) regulates ECM turnover, and its bioavailability is influenced by glycosaminoglycans (GAGs). This study aimed to develop a methacrylated gelatin (GelMA)-based hydrogel functionalized with acrylated sulfated hyaluronan (sHA

Indexed as

Glycosaminoglycans (GAGs)HydrogelMatrix degradationMatrix metalloprotease-9 (MMP-9)Tissue inhibitor of metalloproteinase-3 (TIMP-3)

Identifiers

PMID41732672
PMCPMC12924898

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.