ArticleJournal of oral biology and craniofacial research
Chitosan-gelatin scaffold reinforced with carbonate hydroxyapatite enhances bone healing in rat extraction sockets: An immunohistochemical study.
Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Authors and funding
9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Tooth extraction commonly leads to alveolar bone loss, which can compromise future prosthetic rehabilitation. Biomaterial-based socket preservation aims to support hard-tissue healing and stabilize the extraction site. Objective: To assess the effect of a chitosan-gelatin scaffold reinforced with carbonate hydroxyapatite (CG-CHA) on bone healing in Wistar rats extraction sockets by evaluating immunohistochemical expression of Bone morpogenetic protein 2 (BMP-2), Runt-related transcription factor 2 (RUNX2) and Receptor activator of nuclear κB (RANK). Materials and methods: A true-experimental randomized post-test only control group design was used with 24 male Wistar rats. Following maxillary molar extraction, rats were assigned to either a control group (extraction only) or a CG-CHA scaffold group (n = 12 each). Mandibles were collected on days 7, 14, and 21 (n = 4 per time point per group). Immunohistochemistry were performed to evaluate the expression of BMP-2, RUNX2, and RANK. Data were analyzed using independent t-tests with significance at p < 0.05. Results: The CG-CHA group showed greater bone formation and significantly higher BMP-2, RUNX2, and RANK expression at days 7, 14, and 21 compared to controls (p < 0.05). Conclusion: Placement of a CG-CHA scaffold in extraction sockets improved bone healing and increased osteogenic marker expression in rats. These findings indicate that CG-CHA supports favorable socket healing and may be useful for alveolar bone preservation strategies.
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