ArticleTherapeutic advances in medical oncology2026
Induction chemotherapy administration increases the risk of radiation pneumonitis in unresectable stage III NSCLC patients undergoing concurrent chemoradiotherapy with immunotherapy.
Article in Therapeutic advances in medical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Concurrent chemoradiotherapy (cCRT) is essential for stage III unresectable non-small cell lung cancer (NSCLC) but increases the risk of radiation pneumonitis (RP), especially with immunotherapy (IO). Induction chemotherapy (ICT) controls tumor progression but damages lung tissue, raising RP risk. Research on the RP risk from ICT, cCRT, and IO consolidation is poorly investigated. Objectives: We evaluated whether ICT increases RP incidence and affects survival in the IO era. Design: This was a retrospective analysis conducted at a single cancer center. Methods: Retrospective data from stage III unresectable NSCLC patients treated with cCRT and IO between 2018 and 2024 were analyzed. Patients were divided into cCRT without ICT ( Results: The ICT before cCRT group showed a higher incidence of ⩾Grade 2 RP compared to the cCRT without ICT group (Gray's test, SHR = 1.964, 95% confidence interval (CI): 1.137-3.394, Conclusion: ICT followed by cCRT showed a higher incidence of ⩾Grade 2 RP compared to cCRT alone in patients with unresectable stage III NSCLC receiving consolidation immunotherapy.
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