Evidence map›Paper›PMID 41732650›Full record

ArticleCureus2026

Room to Move: Enhancing Head and Neck Radiotherapy With a Six-Degree-of-Freedom Couch.

Peter L Lee, Joseph V Panetta, Alexander P Lukez, Mihir K Karande, Thomas J Galloway

Abstract read
In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Peter L LeeDepartment of Radiation Oncology, Mass General Brigham, Boston, USA.
Joseph V PanettaDepartment of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, USA.
Alexander P LukezDepartment of Radiation Oncology, University of Vermont Medical Center, Burlington, USA.
Mihir K KarandeDepartment of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, USA.
Thomas J GallowayDepartment of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose Image-guided radiation therapy (IGRT) allows for a reduction in target volume margins, but relies on accurate daily set-up. Six-degree-of-freedom couches offer rotational adjustments during alignment. Given the often large and irregular target volumes treated in head and neck (H&N) cancers, rotational errors may contribute significantly to inter-fraction variability in both target coverage and critical-structure dose. We seek to evaluate the impact of rotational adjustments on target coverage and critical-structure dose in H&N radiotherapy. Methods We reviewed 214 radiotherapy fractions for H&N cancer. Patients were treated using a six-degree-of-freedom couch that allows a maximum of ±3° of roll, pitch, and yaw, in addition to linear shifts. Daily couch adjustments were recorded, and the CT simulation images and treatment plan were imported into the oncology management system to allow fusion. The delivered dose was recalculated with and without rotational components, with deviation thresholds for planning target volume (PTV) V70Gy coverage taken to be 3% and 5%. Results A rotational shift in at least one plane was used on 212 of 214 treatment fractions. Without rotational shifts, PTV V100% was lower by a median of 1.97% (1.77%-2.18%; 95% CI) compared to the planned coverage. Specifically, 43 (20%) fractions had a decrease in PTV V100% of ≥3% when rotational shifts were not applied, and 10 (4.7%) fractions had a decrease in PTV V100% of ≥5%. All 43 fractions with a ≥3% drop in PTV coverage required at least 1.5° rotational correction in at least one direction. Organs at risk (OAR) dose was less dependent on rotational correction, without significant correlations between the magnitude of rotational correction and increased OAR dose. Conclusion Rotational corrections are applied frequently when treating H&N cancers on a six-degree-of-freedom couch. Rotational adjustments had the greatest benefit on PTV coverage, while OAR doses were less dependent. These data highlight the utility of a six-degree-of-freedom couch for H&N radiotherapy and suggest a target set-up goal of less than 1.5° rotational error in all planes.

Indexed as

head and neck oncologyhead and neck radiationimage guided radiotherapyimmobilizationradiation simulation

Identifiers

PMID41732650
PMCPMC12925378

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.