ArticleCJC open2026
Effects of Reducing Sedentary Behaviour on Cardiac Structure and Function at Rest and During Exercise: A 6-Month Randomized Controlled Trial.
Article in CJC open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03101228 (Medical and Physiological Benefits and Mechanisms of Reduced Sitting Without Meeting the Current Physical Activity Recommendations), which is not on this map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Medical and Physiological Benefits and Mechanisms of Reduced Sitting Without Meeting the Current Physical Activity Recommendations
Who cites it
5 citing papers in PubMed.
- Changes in hemoglobin levels and cardiometabolic health in adults with metabolic syndrome - a secondary outcome analysis of a six-month randomized controlled trial.Annals of medicine · 2026Trial
- Associations of light and moderate-to-vigorous physical activity with health-related outcomes: findings from the FINFIT 2017 and 2021 studies.Annals of medicine · 2026Article
- Apical hypercontractility mitigates impaired diastolic filling and lower intraventricular haemodynamic forces in human bed rest.Experimental physiology · 2026Article
- Exercise reverses the sedentary cardiac phenotype in obesity: a systematic review and meta-analysis of hemodynamic, structural, and functional adaptations.BMC sports science, medicine & rehabilitation · 2026Article
- Longitudinal Insights Into Pediatric Hypertension, Cardiac Consequences, and Physical Activity.Current hypertension reports · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Interventional studies on sedentary behaviour (SB) and cardiac health are missing. Therefore, this study investigates the effects of reducing SB on cardiac structure and function in inactive and sedentary adults with metabolic syndrome. Methods: In this randomized controlled trial, the intervention group (n = 33) aimed at reducing SB by 1 h/d for 6 months. The control group (n = 31) continued their SB and physical activity (PA) as usual. All participants wore accelerometers throughout the study. Echocardiography was performed at rest and during incremental exercise tests before and after the intervention. Results: No intervention effects were observed in any echocardiographic variables between the randomized groups. However, when participants were regrouped into a less sedentary (mean SB reduction 60 min/d) or a continuously sedentary group, based on their actual measured behaviour change, left ventricular (LV) mass index and end-diastolic diameter decreased more in the less sedentary than in the continuously sedentary group (group x time Conclusions: A 6-month intervention aimed at reducing SB did not affect cardiac structure or function. However, in participants with successful SB reduction and increased light PA regardless of original randomization, LV mass index may have decreased, and LV function during exercise may have improved. Clinical Trial Registration: NCT03101228.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.